Day 45 Change from Baseline | Â | Â | Â | Â | Â | Â | ||
---|---|---|---|---|---|---|---|---|
Gene | SNP/Allele | Genotype | AC1202 | n | Placebo | n | p-value* | Difference (CI) |
APOE | APOE | 3/2 | -1.222 | 3 | 5.167 | 2 | 0.182 | 6.389(-3.050, 15.828) |
APOE | APOE | 3/3 | -2.317 | 20 | 2.999 | 23 | 0.001 | 5.315(2.154, 8.476) |
APOE | APOE | 4/2 | 2.778 | 3 | . | 0 | na | na |
APOE | APOE | 4/3 | 1.107 | 28 | 2.175 | 19 | 0.492 | 1.068(-2.005, 4.142) |
APOE | APOE | 4/4 | -1.667 | 3 | -1.167 | 10 | 0.884 | 0.500(-6.306, 7.306) |
IDE | rs2251101 | C | 2.375 | 8 | -0.905 | 7 | 0.138 | 3.280(-1.076, 7.635) |
IDE | rs2251101 | Het | -1.647 | 17 | 2.317 | 23 | 0.004 | 3.964(1.273, 6.656) |
IDE | rs2251101 | T | -0.711 | 30 | 1.290 | 23 | 0.092 | 2.001(-0.331, 4.333) |
IDE c/c | IDE c/c (-) | IDE - | -1.050 | 47 | 1.804 | 46 | 0.002 | 2.853(1.100, 4.606) |
IDE c/c | IDE c/c (+) | IDE + | 2.375 | 8 | -0.905 | 7 | 0.140 | 3.280(-1.094, 7.654) |
IL1B | rs1143627 | C | 1.000 | 5 | 2.481 | 9 | 0.545 | 1.481(-3.365, 6.328) |
IL1B | rs1143627 | Het | -1.097 | 24 | -0.020 | 17 | 0.439 | 1.078(-1.677, 3.832) |
IL1B | rs1143627 | T | -0.768 | 23 | 2.026 | 24 | 0.031 | 2.795(0.259, 5.330) |
IL1B | rs16944 | C | -0.768 | 23 | 2.026 | 24 | 0.031 | 2.795(0.259, 5.330) |
IL1B | rs16944 | Het | -1.097 | 24 | -0.020 | 17 | 0.439 | 1.078(-1.677, 3.832) |
IL1B | rs16944 | T | 1.000 | 5 | 2.481 | 9 | 0.545 | 1.481(-3.365, 6.328) |
Day 90 Change from Baseline | Â | Â | Â | Â | Â | Â | ||
APOE | APOE | 3/2 | 3.667 | 1 | 6.333 | 1 | 0.737 | 2.667(-13.098, 18.431) |
APOE | APOE | 3/3 | -2.579 | 19 | 1.398 | 20 | 0.029 | 3.977(0.406, 7.548) |
APOE | APOE | 4/2 | -3.667 | 2 | . | 0 | na | na |
APOE | APOE | 4/3 | 1.302 | 21 | 0.471 | 17 | 0.651 | 0.831(-2.806, 4.468,) |
APOE | APOE | 4/4 | 1.667 | 2 | 0.867 | 10 | 0.854 | 0.800(-7.835, 9.435) |
IDE | rs2251101 | C | 3.905 | 7 | -1.857 | 7 | 0.047 | 5.762(0.074, 11.450) |
IDE | rs2251101 | Het | -2.769 | 13 | 2.944 | 19 | 0.004 | 5.713(1.883, 9.543) |
IDE | rs2251101 | T | -0.931 | 24 | 0.446 | 21 | 0.392 | 1.377(-1.803, 4.556) |
IDE c/c | IDE c/c (-) | IDE - | -1.577 | 37 | 1.633 | 40 | 0.011 | 3.209(0.766, 5.652) |
IDE c/c | IDE c/c (+) | IDE + | 3.905 | 7 | -1.857 | 7 | 0.049 | 5.762(0.038, 11.486) |
IL1B | rs1143627 | C | -1.083 | 4 | 1.815 | 9 | 0.396 | 2.898(-3.859, 9.656) |
IL1B | rs1143627 | Het | -0.193 | 19 | -0.044 | 15 | 0.940 | 0.149(-3.735, 4.033) |
IL1B | rs1143627 | T | -1.947 | 19 | 1.748 | 20 | 0.044 | 3.696(0.093, 7.298) |
IL1B | rs16944 | C | -1.947 | 19 | 1.748 | 20 | 0.044 | 3.696(0.093, 7.298) |
IL1B | rs16944 | Het | -0.193 | 19 | -0.044 | 15 | 0.940 | 0.149(-3.735, 4.033) |
IL1B | rs16944 | T | -1.083 | 4 | 1.815 | 9 | 0.396 | 2.898(-3.859, 9.656) |
Day 104 Change from Baseline | Â | Â | Â | Â | Â | Â | ||
APOE | APOE | 3/2 | -1.333 | 3 | 2.333 | 2 | 0.474 | 3.667(-6.443, 13.776) |
APOE | APOE | 3/3 | -0.812 | 23 | 1.384 | 21 | 0.196 | 2.196(-1.147, 5.538) |
APOE | APOE | 4/2 | 0.889 | 3 | . | 0 | na | na |
APOE | APOE | 4/3 | 0.821 | 26 | -0.722 | 18 | 0.370 | 1.543(-1.853, 4.938) |
APOE | APOE | 4/4 | -1.083 | 4 | 0.933 | 10 | 0.543 | 2.017(-4.535, 8.568) |
IDE | rs2251101 | C | 3.762 | 7 | 0.952 | 7 | 0.331 | 2.810(-2.895, 8.514) |
IDE | rs2251101 | Het | -2.169 | 18 | 0.317 | 20 | 0.158 | 2.485(-0.982, 5.953) |
IDE | rs2251101 | T | -0.029 | 33 | 0.867 | 22 | 0.547 | 0.896(-2.042, 3.834) |
IDE c/c | IDE c/c (-) | IDE - | -0.784 | 51 | 0.605 | 42 | 0.217 | 1.389(-0.828, 3.606) |
IDE c/c | IDE c/c (+) | IDE + | 3.762 | 7 | 0.952 | 7 | 0.330 | 2.810(-2.878, 8.497) |
IL1B | rs1143627 | C | 0.778 | 6 | 0.407 | 9 | 0.898 | 0.370(-5.373, 6.114) |
IL1B | rs1143627 | Het | -0.376 | 24 | 0.524 | 14 | 0.627 | 0.900(-2.765, 4.565) |
IL1B | rs1143627 | T | -0.720 | 25 | 0.380 | 23 | 0.490 | 1.100(-2.049, 4.248) |
IL1B | rs16944 | C | -0.720 | 25 | 0.380 | 23 | 0.490 | 1.100(-2.049, 4.248) |
IL1B | rs16944 | Het | -0.376 | 24 | 0.524 | 14 | 0.627 | 0.900(-2.765, 4.565) |
IL1B | rs16944 | T | 0.778 | 6 | 0.407 | 9 | 0.898 | 0.370(-5.373, 6.114) |