Patient's family pedigree displaying breast cancer. Black shading indicates individuals with cancer. The patient (proband) is individual III:2 and is arrowed. The current age and the age at diagnosis of cancers are indicated below. The genotypes (where DNA available for analyses) are shown as: - for wild-type homozygous, and + for heterozygous for BRCA1 complete deletion. PC: prostate cancer; CLL: chronic lymphocytic leukaemia; CRC: colorectal cancer; BC: breast cancer; Bi BC: bilateral breast cancer.