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Table 3 Genotype and allele association analysis of 5 single nucleotide polymorphisms

From: Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population

SNP ID

Polymorphisms

Genotype/allele

Patients with

asthma, n (%)

Controls, n (%)

OR

95% CI

P value

P*

rs7216389

(GSDMB)

TT

384 (55.2)

298 (46.8)

1

   
 

CT

258 (37.1)

286 (44.9)

1.43

1.14-1.80

0.008

 
 

CC

54 (7.7)

53 (8.3)

1.27

0.84-1.90

 

0.01

 

T

1026 (73.7)

882 (69.2)

1

 

0.011

 
 

C

366 (26.3)

392 (30.8)

1.25

1.05-1.48

  

rs12603332

(ORMDL3)

CC

385 (54.2)

302 (46.04)

1

   
 

CT

268 (37.8)

300 (45.73)

1.43

1.14-1.784

0.007

 
 

TT

57 (8.0)

54 (8.23)

1.21

0.81-1.81

 

0.01

 

C

1038 (73.1)

904 (68.9)

1

 

0.016

 
 

T

382 (26.9)

408 (31.1)

1.23

1.04-1.45

  

rs12936231

(ZPBP2)

CC

393 (56.1)

298 (47.8)

1

   
 

CG

257 (36.7)

278 (44.6)

1.43

1.14-1.79

0.009

 
 

GG

50 (7.1)

47 (7.5)

1.24

0.81-1.90

 

0.01

 

C

1043 (74.5)

874 (70.0)

1

 

0.013

 
 

G

357 (25.5)

372 (30.0)

1.24

1.05-1.48

  

rs11557467

(ZPBP2)

GG

383 (55.51)

300 (46.80)

1

   
 

GT

257 (37.25)

288 (44.93)

1.43

1.14-1.79

0.006

 
 

TT

50 (7.25)

53 (8.27)

1.35

0.89-2.05

 

0.005

 

G

1023 (74.13)

888 (69.27)

1

 

0.006

 
 

T

357 (25.87)

394 (30.73)

1.27

1.07-1.51

  

rs9303277

(IKZF3)

CC

348 (50.58)

269 (42.43)

1

   
 

CT

278 (40.41)

295 (46.53)

1.37

1.09-1.73

0.012

 
 

TT

62 (9.01)

70 (11.04)

1.46

1.00-2.13

 

0.004

 

C

974 (70.78)

833 (65.69)

1

 

0.005

 
 

T

402 (29.22)

435 (34.31)

1.27

1.07-1.49

  
  1. SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval; P* adjusted for age and sex