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Table 4 Longitudinal association of TNFA -863 polymorphism with pulmonary function and BODE index in COPD patients

From: TNFA-863 polymorphism is associated with a reduced risk of Chronic Obstructive Pulmonary Disease: A replication study

Parameter SNP Genotype Time P-value
   baseline 1° year 2° year  
FEV1 % pred CC 55.2 ± 20.1 52.1 ± 18.7 49.1 ± 19.7 0.004
  CA+AA 64.9 ± 21.6 61.3 ± 19.4 62.0 ± 17.1  
  P-value 0.003 0.017 0.002  
BODE CC 2 (0-5) 2(0-6) 2(0-6) 0.003
  CA+AA 1 (0-4) 1(0-4) 1(0-4)  
  P-value 0.001 0.006 0.016  
  1. Data are presented as mean ± standard deviation (X ± SD) for FEV1 % pred and compared by T-Student test. The Bode index was summarized as median (5th-95th pc) and compared by U-Mann Whitney test. Global p-value for GLIM test for repeated measures inter-groups.