BMC Medical Genetics

Table 4 Longitudinal association of TNFA -863 polymorphism with pulmonary function and BODE index in COPD patients

From: TNFA-863 polymorphism is associated with a reduced risk of Chronic Obstructive Pulmonary Disease: A replication study

Parameter	SNP Genotype	Time			P-value^†
		baseline	1° year	2° year
FEV₁ % pred	CC	55.2 ± 20.1	52.1 ± 18.7	49.1 ± 19.7	0.004
	CA+AA	64.9 ± 21.6	61.3 ± 19.4	62.0 ± 17.1
	P-value	0.003	0.017	0.002
BODE	CC	2 (0-5)	2(0-6)	2(0-6)	0.003
	CA+AA	1 (0-4)	1(0-4)	1(0-4)
	P-value	0.001	0.006	0.016

Data are presented as mean ± standard deviation (X ± SD) for FEV₁ % pred and compared by T-Student test. The Bode index was summarized as median (5^th-95^th pc) and compared by U-Mann Whitney test. ^† Global p-value for GLIM test for repeated measures inter-groups.

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