Table 2 Association of SNPs in the LTA and TNFA genes with Chronic Obstructive Pulmonary Disease (COPD)
COPD cases vs. healthy control | ||||||
|---|---|---|---|---|---|---|
Gene position | SNP ID | Seattle SNP database | COPD cases MAF % | Healthy controls MAF % | ORadj (95% CI) a | P-value* |
LTA | ||||||
+49(C/A) | rs2239704 | Lt_2202 | 0.42 | 0.39 | 1.05 (0.79-1.4) | 0.73 |
+252(A/G) | rs909253 | Lt_2374 | 0.30 | 0.30 | 1.08 (0.79-1.46) | 0.63 |
+495(T/C) | rs2229094 | Lt_2619 | 0.31 | 0.33 | 0.83 (0.62-1.11) | 0.2 |
+720(C/A) | rs1041981 | Lt_2847 | 0.29 | 0.30 | 1.05 (0.77-1.42) | 0.78 |
TNFA | ||||||
-863(C/A) | rs1800630 | Lt_4539 | 0.16 | 0.22 | 0.58 (0.41-0.83) | 0.002 |
0.50 (0.33-0.77) | 0.001** | |||||
-857(C/T) | rs1799724 | Lt_4545 | 0.09 | 0.09 | 1.41 (0.88-2.27) | 0.16 |
-376(G/A) | rs1800750 | TNF_214 | 0.04 | 0.03 | 1.30 (0.64-2.66) | 0.47 |
-308(G/A) | rs1800629 | TNF_282 | 0.15 | 0.15 | 0.97 (0.66-1.42) | 0.87 |
-238(G/A) | rs361525 | TNF_352 | 0.06 | 0.06 | 1.25 (0.72-2.19) | 0.43 |
+489(G/A) | rs180610 | TNF_1078 | 0.09 | 0.09 | 1.42 (0.88-2.22) | 0.15 |