Association of HLA-B*5801 allele and allopurinol-induced stevens johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis

Table 3 Number of patients who had HLA-B5801* allele positive and summary odds ratios

Author	Year	HLA-B5801* Positive/Total		Odds Ratio (OR)	95% Confidence Interval
		SJS/TEN Cases (n)	Controls (n)
Matched-control
Hung SI [10]	2005	21/21	20/135	242.27	14.11-4158.76
Tassaneeyakul W [13]	2009	27/27	7/54	348.33	19.15-6336.86
Kang HR [14]	2011	4/5	6/57	34.00	3.25-356.12
Jung JW [15]	2011	2/2	41/432	47.17	2.23-999.15
*Pooled OR*				*96.60*	*24.49-381.00*
Population-control
Hung SI [10]	2005	21/21	19/93	164.28	9.52-2833.92
Kaniwa N [11]	2008	4/10	6/493	54.11	12.08-242.41
Lonjou C [12]	2008	19/31	28/1822	101.45	44.98-228.82
Kang HR [14]	2011	4/5	59/485	28.88	3.17-262.79
Jung JW [15]	2011	2/2	59/485	35.84	1.70-755.61
*Pooled OR*				*79.28*	*41.53-151.35*

Abbreviations: SJS = Stevens-Johnson Syndrome, TEN = Toxic Epidermal Necrolysis; OR = Odds Ratio

ISSN: 1471-2350