Association of HLA-B*5801 allele and allopurinol-induced stevens johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis

Table 2 Patients' demographic information

Author	Year	% Male		Mean age, yr (range)		Ethnicity	Country	Allopurinol Dose, mg/day (range)		Actual Duration of Allopurinol Exposure
		SJS/TEN Cases	Controls	SJS/TEN Cases	Controls			Cases	Control	Cases	Control
Hung SI [10]	2005	52.4	92.6^a	62.4 (25-91)	56.0 (21-84)^b	Han Chinese	Taiwan	100 (50-300)	150 (100-400)	26 d (~1-56 d)	22 m (6-107 m)
Kaniwa N [11]	2008	80.0	NA	70.9 (53-83)	NA	Japanese	Japan	NR	NR	NR	NR
Lonjou C [12]	2008	58.1	NA	55.0 (21-83)	NA	Mixed European Population^c	NR	NR	NR	NR	NR
Tassaneeyakul W [13]	2009	55.6	79.63	65.0 (38-81)	63.5 (46-90)	Thai	Thailand	NR	NR	14 d (3-50 d)	26 m (3-600 m)
Kang HR [14]	2011	60.0	64.9^d	50.0 (42-80)	51.0 (20-76)^d	Korean	Korea	200 (100-300)	100 (50-200)	0.7 m (0.2-1.1 m)	29.1 m (6-72 m)
Jung JW [15]	2011	43.8	73.6^d	41.4 (27-56)	35.9 (18-54)^d	Korean	Korea	112.5 (74-151)	100 (50-150)	59 d (14-105 d)	887 d (66-1708 d)

Abbreviations: SJS = Stevens-Johnson Syndrome, TEN = Toxic Epidermal Necrolysis; NR = No Report; NA = Not Applicable; d = day(s); m = month(s)
^a The percent male of matched-controls (% male in population controls is 55.91).
^b Mean age in matched-controls (mean age in population controls is 53.9 (22-91)).
^c Including Asian, South American, African, and European.
^d The values from matched-controls group.

ISSN: 1471-2350