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Table 4 Haplotype analysis of the HMOX1 gene

From: Effect of heme oxygenase-1 polymorphisms on lung function and gene expression

 

Rate of decline study

 

Baseline study

 

Haplotype†

Fast decline

Non decline

P value*

Low function

High function

P value*

ATGGG

0.299

0.309

0.71

0.326

0.342

0.47

GAGAA

0.492

0.450

 

0.474

0.455

 

GAGGA

0.095

0.111

 

0.084

0.100

 

GTCGA

0.057

0.064

 

0.048

0.048

 

GTGGG

0.046

0.056

 

0.051

0.042

 
  1. Haplotype frequencies were estimated with an EM algorithm implemented in haplo.stats.
  2. † Haplotypes formed from polymorphisms in the following order: rs9610289, rs2071746, rs2071747, rs2071749, rs2285112.
  3. * P values are adjusted by multivariate logistic regression for age, sex, pack-years of smoking, and research center. P values are derived from a global test of the difference in distribution of the five haplotypes between the two phenotypic groups.