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Table 2 S-COMT methylation [% ± SD] with respect to COMT genotypes in Saliva DNA (twin cohort)

From: Association of COMT genotypes with S-COMT promoter methylation in growth-discordant monozygotic twins and healthy adults

Variant

CG1

CG2b

mean

CG1

CG2b

mean

CG1

CG2b

mean

p-value

rs6269

AA 34.7 ± 14.7

43.4 ± 18.0

39.0 ± 16.2 (n = 10)

AG 30.9 ± 6.1

40.5 ± 7.8

35.7 ± 6.8 (n = 24)

GG 23.1 ± 9.3

31.9 ± 11.9

27.5 ± 10.6 (n = 6)

< 0.05 *

rs4633

CC 24.7 ± 8.2

33.2 ± 10.1

28.9 ± 9.1 (n = 8)

CT 31.2 ± 6.2

41.0 ± 7.8

36.1 ± 6.8 (n = 22)

TT 34.7 ± 14.7

43.4 ± 18.0

39.0 ± 16.2 (n = 10)

< 0.05 *

rs4680

AA 34.7 ± 14.7

43.4 ± 18.0

39.0 ± 16.2 (n = 10)

AG 31.2 ± 6.2

41.0 ± 7.8

36.1 ± 6.8 (n = 22)

GG 24.7 ± 8.2

33.2 ± 10.1

28.9 ± 9.1 (n = 8)

< 0.05 *

  1. * rs6269: AG vs. GG p < 0.05; rs4633: CC vs. CT p < 0.05; rs4680: AG vs. GG p < 0.05. Please note that shown p-values were calculated using t-tests, which does not take the interrelatedness of the observations into account.
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