Table 2 Characteristics of hypertensive subjects according to the C242T polymorphism
Variable | Campinas | p | Vitória | p | ||
|---|---|---|---|---|---|---|
Genotype (N) | CT + TT (249) | CC (192) | CT + TT (65) | CC (55) | ||
Age, years | 57.2 ± 0.8 | 56.4 ± 0.9 | 0.573 | 54.2 ± 1.2 | 57.3 ± 1.2 | 0.078 |
Gender (M/F) | 101/148 | 76/116 | 0.912 | 20/45 | 24/31 | 0.205 |
Weight, kg | 80 ± 1 | 77 ± 1 | 0.075 | 80 ± 1 | 80 ± 2 | 0.727 |
Height, cm | 160 ± 1 | 159 ± 1 | 0.318 | 158 ± 1 | 161 ± 1 | 0.015 |
Body mass index, kg/m2 | 31.5 ± 0.3 | 30.6 ± 0.4 | 0.118 | 31.9 ± 0.4 | 30.9 ± 0.5 | 0.143 |
Systolic BP, mmHg | 148 ± 1 | 146 ± 1 | 0.457 | 143 ± 2 | 144 ± 2 | 0.702 |
Diastolic BP, mmHg | 85 ± 1 | 86 ± 1 | 0.762 | 91 ± 2 | 94 ± 2 | 0.359 |
Diabetes mellitus, n (%) | 81 (32) | 40 (21) | 0.008 | 10 (15) | 6 (11) | 0.653 |
Smokers, n (%) | 25 (10) | 21 (11) | 0.885 | 14 (21) | 7 (13) | 0.305 |
Coronary heart disease, n (%) | 36 (14) | 34 (18) | 0.426 | 2 (3) | 2 (4) | 0.864 |
LDL-cholesterol, mg/dL | 112 ± 2 | 112 ± 2 | 0.829 | 124 ± 5 | 117 ± 4 | 0.291 |
HDL-cholesterol, mg/dL | 51 ± 1 | 52 ± 1 | 0.748 | 43 ± 1 | 45 ± 1 | 0.401 |
Triglycerides, mg/dL | 162 ± 6 | 148 ± 6 | 0.100 | 195 ± 13 | 182 ± 13 | 0.501 |
Glucose, mg/dL | 116 ± 3 | 106 ± 3 | 0.030 | 117 ± 6 | 106 ± 6 | 0.184 |
Uric acid, mg/dL | 5.9 ± 0.1 | 6.1 ± 0.1 | 0.344 | 5.5 ± 0.1 | 5.4 ± 0.1 | 0.779 |
Creatinine clearance rate, mL/min | 88 ± 2 | 91 ± 2 | 0.409 | 88 ± 4 | 86 ± 4 | 0.733 |
Diuretics, n (%) | 188 (75) | 154 (80) | 0.289 | 26 (40) | 25 (45) | 0.676 |
Calcium channel blockers, n (%) | 124 (50) | 97 (51) | 0.956 | 8 (12) | 7 (13) | 0.944 |
Beta-Blockers, n (%) | 117 (47) | 86 (45) | 0.717 | 15 (23) | 13 (24) | 0.942 |
ACEI or ARB, n (%) | 191 (77) | 153 (79) | 0.526 | 32 (49) | 19 (34) | 0.151 |