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Table 2 Association analysis of TNFRSF1B SNPs with type 2 diabetes in Indo-European population from North India

From: No association of TNFRSF1B variants with type 2 diabetes in Indians of Indo-European origin

 

Initial phase

   

Replication phase

   

Meta-analysis

 
 

Genotype distribution

   

Genotype distribution

     

SNP

Type 2 diabetes patients

Control

Subjects

OR

(95%CI)

P

Type 2 diabetes patients

Control

Subjects

OR

(95%CI)

P

ORr/

ORf

P r/

Pf

rs496888 (A/G)*

(Intron 1)

669 (66.0)

299 (29.6)

45 (4.4)

642 (64.5)

314 (31.5)

40 (4.0)

0.95

(0.81-1.11)

0.484

      

rs6697733 (T/C)*

(Intron 1)

536 (52.8)

404 (39.7)

76 (7.5)

544 (54.1)

400 (39.9)

61 (6.0)

1.07

(0.93-1.24)

0.346

      

rs945439 (T/C)

(Exon 2)

540 (53.3)

395 (38.8)

80 (7.9)

566 (56.3)

386 (38.5)

53 (5.3)

1.17

(1.01-1.36)

0.036

546 (54.0)

393 (38.9)

72 (7.1)

523 (52.2)

404 (40.3)

75 (7.5)

0.94

(0.81-1.08)

0.364

1.05/1.04

0.686/0.420

rs235249 (T/C)

(Intron 8)

503 (51.6)

392 (40.2)

80 (8.2)

545 (55.6)

385 (39.2)

51 (5.2)

1.22

(1.05-1.41)

0.010

561 (54.6)

391 (38.1)

75 (7.3)

536 (53.1)

399 (39.5)

75 (7.4)

0.95

(0.82-1.09)

0.440

1.07/1.06

0.583/0.227

rs17884213 (G/A)

(Intron 9)

550 (54.3)

376 (37.0)

88 (8.7)

564 (56.1)

390 (38.9)

50 (5.0)

1.17

(1.02-1.36)

0.031

569 (56.7)

373 (37.1)

62 (6.2)

525 (53.0)

407 (41.1)

58 (5.9)

0.92

(0.80-1.07)

0.289

1.04/1.04

0.733/0.432

  1. Association was assessed assuming additive model adjusted for age, sex and BMI. The significant associations are highlighted in bold text. OR: odds ratio; CI: confidence interval; ORr: odds ratio for random effects meta-analysis; ORf: odds ratio for fixed effects meta-analysis. * SNPs not genotyped in the replication phase.