From: No association of TNFRSF1B variants with type 2 diabetes in Indians of Indo-European origin
Initial phase | Replication phase | Meta-analysis | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Genotype distribution | Genotype distribution | |||||||||
SNP | Type 2 diabetes patients | Control Subjects | OR (95%CI) | P | Type 2 diabetes patients | Control Subjects | OR (95%CI) | P | ORr/ ORf | P r/ Pf |
rs496888 (A/G)* (Intron 1) | 669 (66.0) 299 (29.6) 45 (4.4) | 642 (64.5) 314 (31.5) 40 (4.0) | 0.95 (0.81-1.11) | 0.484 | ||||||
rs6697733 (T/C)* (Intron 1) | 536 (52.8) 404 (39.7) 76 (7.5) | 544 (54.1) 400 (39.9) 61 (6.0) | 1.07 (0.93-1.24) | 0.346 | ||||||
rs945439 (T/C) (Exon 2) | 540 (53.3) 395 (38.8) 80 (7.9) | 566 (56.3) 386 (38.5) 53 (5.3) | 1.17 (1.01-1.36) | 0.036 | 546 (54.0) 393 (38.9) 72 (7.1) | 523 (52.2) 404 (40.3) 75 (7.5) | 0.94 (0.81-1.08) | 0.364 | 1.05/1.04 | 0.686/0.420 |
rs235249 (T/C) (Intron 8) | 503 (51.6) 392 (40.2) 80 (8.2) | 545 (55.6) 385 (39.2) 51 (5.2) | 1.22 (1.05-1.41) | 0.010 | 561 (54.6) 391 (38.1) 75 (7.3) | 536 (53.1) 399 (39.5) 75 (7.4) | 0.95 (0.82-1.09) | 0.440 | 1.07/1.06 | 0.583/0.227 |
rs17884213 (G/A) (Intron 9) | 550 (54.3) 376 (37.0) 88 (8.7) | 564 (56.1) 390 (38.9) 50 (5.0) | 1.17 (1.02-1.36) | 0.031 | 569 (56.7) 373 (37.1) 62 (6.2) | 525 (53.0) 407 (41.1) 58 (5.9) | 0.92 (0.80-1.07) | 0.289 | 1.04/1.04 | 0.733/0.432 |