Table 4 Genotype and allele frequencies of RPSA polymorphisms in controls and sporadic CJD patients
| Â | 5'-UTR -8T>C | 134-32C>T | 519G>A | 793+58C>T | ||||
|---|---|---|---|---|---|---|---|---|
| Â | Controls (n = 189) | Sporadic CJDs (n = 180) | Controls (n = 50) | Sporadic CJDs (n = 50) | Controls (n = 50) | Sporadic CJDs (n = 50) | Controls (n = 50) | Sporadic CJDs (n = 50) |
Genotype | Â | Â | Â | Â | Â | Â | Â | Â |
1/1 | 91 (48.2%) | 87 (48.3%) | 33 (66.0%) | 33 (66.0%) | 34 (68.0%) | 33 (66.0%) | 28 (56.0%) | 24 (48.0%) |
1/2 | 77 (40.7%) | 78 (43.3%) | 15 (30.0%) | 15 (30.0%) | 14 (28.0%) | 15 (30.0%) | 12 (24.0%) | 22 (44.0%) |
2/2 | 21 (11.1%) | 15 (8.4%) | 2 (4.0%) | 2 (4.0%) | 2 (4.0%) | 2 (4.0%) | 10 (20.0%) | 4 (8.0%) |
P-value | 0.646 | 1.000 | 1.000 | 0.058 | ||||
Allele | Â | Â | Â | Â | Â | Â | Â | Â |
1 | 279 (0.70) | 252 (0.70) | 81 (0.81) | 81 (0.81) | 82 (0.82) | 81 (0.81) | 68 (0.68) | 70 (0.70) |
2 | 119 (0.30) | 108 (0.30) | 19 (0.19) | 19 (0.19) | 18 (0.18) | 19 (0.19) | 32 (0.32) | 30 (0.30) |
P-value | 0.976 | 1.000 | 0.856 | 0.760 | ||||