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Table 3 SNPs with differential association (p < 0.001) with LVM among High and Low Waist Circumference (WC)"

From: A follow-up study for left ventricular mass on chromosome 12p11 identifies potential candidate genes

     

Overall (N = 897)

High WC (N = 495)

Low WC (N = 402)

  

SNP

MB

Gene

Function

Minor Allele

Beta

SE

P*

Beta

SE

P*

Beta

SE

P*

Difference in Betas

P†

rs1157480

30.264

TMTC1

flanking

A

0.004

0.014

7.88E-01

0.053

0.019

6.30E-03

-0.056

0.021

8.20E-03

0.109

1.37E-04

rs1124636

26.424

ITPR2

intron

T

-0.016

0.014

2.54E-01

0.032

0.019

9.31E-02

-0.072

0.020

2.85E-04

0.104

1.45E-04

rs9669515

30.261

TMTC1

flanking

T

0.002

0.014

8.74E-01

0.049

0.019

1.04E-02

-0.055

0.021

8.68E-03

0.104

2.31E-04

rs7970841

30.274

TMTC1

flanking

T

-0.007

0.015

6.31E-01

0.042

0.020

3.04E-02

-0.064

0.021

3.03E-03

0.106

2.46E-04

rs7963790

38.515

SLC2A13

intron

C

0.022

0.013

1.03E-01

0.064

0.017

2.40E-04

-0.030

0.019

1.20E-01

0.095

2.87E-04

rs10877703

38.561

SLC2A13

intron

A

0.012

0.013

3.37E-01

0.052

0.017

2.47E-03

-0.041

0.019

3.22E-02

0.093

2.87E-04

rs1679695

28.845

CCDC91

flanking

T

-0.044

0.022

5.20E-02

-0.106

0.028

2.12E-04

0.050

0.035

1.55E-01

0.156

5.56E-04

rs326644

32.293

BICD1

intron

C

-0.009

0.012

4.41E-01

0.024

0.016

1.34E-01

-0.059

0.018

1.23E-03

0.083

5.73E-04

rs261889

32.371

BICD1

intron

T

0.014

0.014

3.40E-01

-0.030

0.019

1.11E-01

0.066

0.021

1.65E-03

0.096

6.18E-04

rs326641

32.291

BICD1

intron

T

0.015

0.014

2.75E-01

0.059

0.018

1.23E-03

-0.032

0.020

1.06E-01

0.091

6.82E-04

rs2650128

32.352

BICD1

intron

G

0.014

0.015

3.32E-01

-0.026

0.019

1.77E-01

0.074

0.023

1.10E-03

0.100

7.10E-04

rs4356315

31.105

DDX11

flanking

G

0.014

0.012

2.38E-01

0.050

0.015

1.18E-03

-0.028

0.017

1.07E-01

0.078

7.21E-04

rs11610493

40.345

PDZRN4

flanking

G

0.014

0.013

2.57E-01

-0.023

0.017

1.70E-01

0.061

0.018

1.05E-03

0.084

7.82E-04

  1. *adjusted for PCA1, PCA2, age, sex, hypertension, diabetes, BMI, WC, and years between LVM and risk factor measurements
  2. † p-value calculated using a normal approximation to test for differences between the beta coefficients of high and low WC.