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Table 1 Summary statistics of cohorts and results of association between Gly482Ser genotypes and BMI.

From: Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1Ais associated with BMI in Tongans

        Co-dominant Dominant Recessive
Population sample size male female mean age* mean_BMI* (kg/m2) risk allele frequency effect estimate (kg/m2)# P effect estimate (kg/m2)# P effect estimate (kg/m2)# P
Maori 110 32 78 48.1 ± 17.7 32.1 ± 7.6 0.833 0.024 ± 1.41 0.99 0.146 ± 1.60 0.93 -0.907 ± 4.52 0.84
Tongans 184 63 121 46.3 ± 14.0 34.0 ± 6.3 0.592 1.397 ± 0.66 0.037 2.341 ± 0.95 0.014 0.940 ± 1.26 0.46
All 294 95 199 47.0 ± 15.5 33.3 ± 6.9 0.686 0.351 ± 0.60 0.56 0.735 ± 0.81 0.366 -0.248 ± 1.29 0.85
  1. * Standard deviation is shown.
  2. # Standard error is shown.
  3. The linear regression model used to produce effect estimates included age and sex as covariates. In the analysis including all populations, "population" was also included as a covariate. Results for all three modes of inheritance (co-dominant, dominant and recessive) are shown. Statistically significant P values (P < 0.05) are shown in bold.
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