The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study

Table 2 Genotypes in Danish patients with Crohns Disease¹.

	N_case	N_control	OR (95%CI)²		OR (95%CI)³		OR (95%CI)⁴		P-value⁵
IL1 β C-31T (rs1143627)
TT	165	342	1.00	-	1.00	-	1.00	-
CT	139	342	0.84	(0.64-0.10)	0.85	(0.65-1.12)	0.86	(0.65-1.14)	0.29
CC	32	95	0.70	(0.45-1.09)	0.71	(0.45-1.10)	0.69	(0.44-1.09)	0.11
CT and CC	171	437	0.81	(0.63-1.05)	0.82	(0.63-1.07)	0.82	(0.63-1.07)	0.15
IL-10 C-592A (rs1800872)
CC	214	483	1.00	-	1.00	-	1.00	-
AC	114	261	0.99	(0.75-1.29)	0.98	(0.75-1.30)	1.01	(0.76-1.34)	0.97
AA	8	35	0.52	(0.24-1.13)	0.53	(0.24-1.16)	0.54	(0.24-1.21)	0.13
AC and AA	122	296	0.93	(0.71-1.21)	0.93	(0.71-1.22)	0.95	(0.72-1.25)	0.72
IL-10 C-819T (rs1800871)
CC	216	483	1.00	-	1.00	-	1.00	-
CT	111	259	0.96	(0.73-1.26)	0.95	(0.72-1.25)	0.97	(0.73-1.29)	0.83
TT	9	37	0.54	(0.26-1.15)	0.55	(0.26-1.18)	0.56	(0.26-1.22)	0.14
CT and TT	120	296	0.91	(0.69-1.18)	0.90	(0.69-1.18)	0.92	(0.70-1.21)	0.55
IL-10 G-1082A (rs1800896)
GG	109	238	1.00	-	1.00	-	1.00	-
AG	171	374	1.00	(0.75-1.33)	0.99	(0.74-1.33)	0.97	(0.72-1.32)	0.87
AA	56	167	0.73	(0.50-1.07)	0.75	(0.51-1.10)	0.78	(0.53-1.16)	0.23
AG and AA	227	541	0.92	(0.70-1.21)	0.92	(0.69-1.21)	0.92	(0.69-1.22)	0.56
(rs3024505)
CC	203	522	1.00	-	1.00	-	1.00	-
CT	114	235	1.25	(0.95-1.64)	1.27	(0.96-1.68)	1.31	(0.98-1.75)	0.07
TT	19	22	2.22	(1.18-4.19)	2.60	(1.36-4.96)	2.48	(1.27-4.84)	0.01
CT and TT	133	779	1.33	(1.02-1.73)	1.37	(1.05-1.80)	1.40	(1.06-1.85)	0.02
HO-1 A-413T (rs2071746)
AA	110	267	1.00	-	1.00	-	1.00	-
AT	165	373	1.07	(0.81-1.43)	1.06	(0.79-1.42)	1.05	(0.78-1.42)	0.75
TT	61	139	1.07	(0.73-1.55)	1.11	(0.76-1.62)	1.04	(0.70-1.53)	0.86
AT and TT	226	512	1.07	(0.82-1.41)	1.08	(0.82-1.42)	1.05	(0.79-1.39)	0.75

ISSN: 1471-2350