Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in Type 2 Diabetes in a Chinese population

Table 2 Association with type 2 diabetes in the Chinese Han population.

Chr	SNPs	Genes	Genotypes distribution ^a		Genotypic P_nominal	Minor/Major Alleles	RAF		Odd ratio (95%CI)	Allelic P_nominal ^c	Allelic P_permuted ^d
			Patients bb/Bb/BB	Controls Bb/Bb/BB			Patients	Controls
9	rs10811661	CDKN2A/B	145:514:343	191:514:279	0.002	C/T	0.60	0.55	1.22(1.06-1.41)	0.005	0.005
8	rs13266634	SLC30A8	149:457:386	179:487:327	0.01	T/C	0.62	0.57	1.19(1.04-1.37)	0.009	0.009
4	rs6446482	WFS1	0:71:914	2:91:880	0.06	C/G	0.96	0.95	1.39(0.98-1.92)	0.06	0.06
10	rs5015480	HHEX	43:336:627	31:290:668	0.04	C/T	0.21	0.18	1.20(1.01-1.42)	0.03	0.03
17	rs7501939	TCF2	89:443:460	73:378:490	0.04	T/C	0.31	0.28	1.12(0.97-1.30)	0.12	0.12
6	rs10946398	CDKAL1	240:472:286	170:498:323	0.0006	C/A	0.48	0.42	1.27(1.11-1.45)	0.0006	0.0008
16	rs8050136	FTO	17:229:761	10:195:790	0.08	A/C	0.13	0.11	1.24(1.01-1.52)	0.041	0.046
3	rs4402960	IGF2BP2	76:418:503	53:356:571	0.001	T/G	0.29	0.24	1.26(1.08-1.47)	0.003	0.003
11	rs2237892	KCNQ1	69:396:525	107:437:415	1.23 × 10^-5	T/C	0.73	0.66	1.37(1.19-1.69)	2.47 × 10^-5	1.0 × 10^-4

a. Genotype distributions are shown as the counts of three genotypes (bb, Bb, and BB). b, Minor allele; B, Major allele. RAF, Risk allele; OR, Risk allele-specific odds ratios calculated by logistic regression analysis. c. Adjusted for age, gender, and BMI. d. Permutation for 10,000 times. Bold indicates the risk allele.

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