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Table 2 Comparison of genotypic frequencies (%) between Coeliac and Control samples (Table 1) and the pooled Coeliac (1 + 2) and Control (1 + 2) samples.

From: Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study

  

A1A1

A1A2

A2A2

p

Coeliac 1 Vs Control 1

     

IL10RA

Coeliac 1

86 (23.1)

192 (51.8)

93 (25.1)

 

rs2256111 A/G

Control 1

69 (19.8)

192 (55.0)

88 (25.2)

0.514

IL10RA

Coeliac 1

255 (68.0)

101 (26.9)

19 (5.1)

 

rs4252272 A/G

Control 1

226 (64.8)

115 (33.0)

8 (2.3)

0.068

IL10RA

Coeliac 1

171 (45.4)

169 (44.8)

37 (9.8)

 

rs2229113 G/A

Control 1

150 (43.7)

167 (48.7)

26 (7.6)

0.426

IL10RA

Coeliac 1

113 (30.3)

191 (51.2)

69 (18.5)

 

rs9610 G/A

Control 1

96 (28.0)

184 (53.6)

63 (18.4)

0.767

CD3E

Coeliac 1

118 (33.3)

178 (50.3)

58 (16.4)

 

rs3782042 G/A

Control 1

133 (39.6)

158 (47.0)

45 (13.4)

0.196

CD3E

Coeliac 1

158 (49.7)

131 (41.2)

29 (9.1)

 

rs1945764 T/C

Control 1

155 (45.9)

160 (47.3)

23 (6.8)

0.223

CD3DG

Coeliac 1

193 (54.4)

137 (38.6)

25 (7.0)

 

rs2276423 G/C

Control 1

171 (49.9)

142 (41.4)

30 (8.8)

0.434

CD3DG

Coeliac 1

240 (66.5)

109 (30.2)

12 (3.3)

 

rs3181259 G/A

Control 1

238 (69.6)

97 (28.4)

7 (2.1)

0.469

CD3DG

Coeliac 1

147 (41.9)

159 (45.3)

45 (12.8)

 

rs1561966 G/A

Control 1

129 (38.2)

170 (50.3)

39 (11.5)

0.422

CD3DG

Coeliac 1

187 (52.5)

139 (39.0)

30 (8.4)

 

rs7949185 T/C

Control 1

183 (53.2)

132 (38.4)

29 (8.4)

0.983

THY1

Coeliac 1

161 (43.5)

171 (46.2)

38 (10.3)

 

rs1894006 G/A

Control 1

161 (47.1)

155 (45.3)

26 (7.6)

0.380

THY1

Coeliac 1

122 (34.3)

173 (48.6)

61 (17.1)

 

rs1001205 G/A

Control 1

127 (37.9)

160 (47.8)

48 (14.3)

0.468

IL18

Coeliac 1

145 (44.2)

147 (44.8)

36 (11.0)

 

rs2043055 A/G

Control 1

116 (38.2)

156 (51.3)

32 (10.5)

0.244

IL18

Coeliac 1

154 (50.3)

135 (44.1)

17 (5.6)

 

* -137 rs187238 G/C

Control 1

184 (54.6)

121 (35.9)

32 (9.5)

0.038

IL18

Coeliac 1

227 (75.7)

68 (22.7)

5 (1.7)

 

rs5744241 A/G

Control 1

237 (82.3)

49 (17.0)

2 (0.7)

0.114

IL18

Coeliac 1

138 (36.6)

192 (51.1)

46 (12.2)

 

* -607 rs1946518 C/A

Control 1

100 (31.1)

153 (47.5)

69 (21.4)

0.005

Coeliac 2 Vs Control 2

 

IL18

Coeliac 2

99 (57.9)

56 (32.7)

16 (9.4)

 

-137 rs187238 G/C

Control 2

272 (52.7)

208 (40.2)

37 (7.1)

0.641

IL18

Coeliac 2

50 (42.4)

48 (40.7)

20 (16.9)

 

-607 rs1946518 C/A

Control 2

201 (37.5)

256 (47.8)

79 (14.7)

0.712

Coeliac (1 + 2) Vs Controls (1 + 2)

   

IL18

Coeliac

253 (53.0)

191 (40.0)

33 (6.9)

 

-137 rs187238 G/C

Control

456 (53.4)

329 (38.5)

69 (8.1)

0.696

IL18

Coeliac

188 (38.1)

240 (48.6)

66 (13.4)

 

-607 rs1946518 C/A

Control

301 (35.1)

409 (47.7)

148 (17.2)

0.042

  1. P values (uncorrected for multiple testing) are for genotype heterogeneity (Genepop). SNPs with a reportedly functional role are marked with an asterisk (*).