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Figure 1 | BMC Medical Genetics

Figure 1

From: SCN5Aallelic expression imbalance in African-Americans heterozygous for the common variant p.Ser1103Tyr

Figure 1

Allelic variation in cardiac SCN5A expression in African-American infants. (A) The log2 p.Tyr1103:p.Ser1103 allelic expression ratios for all cases and controls are plotted as a function of the count and fitted with Gaussian functions (red line). The goodness of fit for a two component model was significantly better than a single mode (p < 0.0001), thus demonstrating a bimodal distribution of allelic expression ratios. (B) Distribution of log2 allelic expression ratios for SIDS cases and controls. Red colored symbols represent subjects with log2 allelic expression ratios significantly different from zero using a Bonferroni corrected level of significance (p < 0.002).

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