Association of MMP - 12 polymorphisms with severe and very severe COPD: A case control study of MMPs - 1, 9 and 12in a European population

Haq, Imran; Chappell, Sally; Johnson, Simon R; Lotya, Juzer; Daly, Leslie; Morgan, Kevin; Guetta-Baranes, Tamar; Roca, Josep; Rabinovich, Roberto; Millar, Ann B; Donnelly, Seamas C; Keatings, Vera; MacNee, William; Stolk, Jan; Hiemstra, Pieter S; Miniati, Massimo; Monti, Simonetta; O'Connor, Clare M; Kalsheker, Noor

doi:10.1186/1471-2350-11-7

Table 5 MMPs -1, 12 and 9 - Genotype frequencies in Controls and Cases

From: Association of MMP - 12 polymorphisms with severe and very severe COPD: A case control study of MMPs - 1, 9 and 12in a European population

Gene	SNP No.	Locus	Genotypes	Controls	COPD all cases	Unadjusted P-value	Adjusted P-value**
*MMP* 1	1	rs2071230	AA/AG/GG	0.85/0.13/0.02	0.85/0.14/0.00	0.01	0.16
	2	rs2239008	GG/GA/AA	0.64/0.33/0.03	0.64/0.31/0.05	0.26	0.28
	3	rs470215	AA/AG/GG	0.39/0.47/0.14	0.40/0.47/0.13	0.61	0.86
	4	rs1938901	CC/CT/TT	0.51/0.41/0.08	0.48/0.42/0.10	0.25	0.22
	5	rs17881293	AA/AG/GG	0.89/0.10/0.01	0.89/0.11/0.00	0.65	0.74
	6	rs17884110	C/C/C	0.39/0.47/0.14	0.41/0.47/0.12	0.42	0.78
	7	rs17878931	AA/AC/CC	0.01/0.25/0.74	0.02/0.25/0.73	0.66	0.33
	8	rs10488	GG/GA/AA	0.89/0.11/0.01	0.88/0.11/0.00	0.6	0.75
	9	rs470358	TT/TC/CC	0.14/0.40/0.46	0.17/0.37/0.46	0.32	0.54
	10	rs3213460	GG/GA/AA	0.73/0.25/0.02	0.72/0.26/0.02	0.84	0.43
	11	rs514921	AA/AG/GG	0.50/0.42/0.08	0.50/0.42/0.08	0.99	0.94
	12	rs498186	AA/AC/CC	0.28/0.52/0.20	0.29/0.48/0.23	0.13	0.39
	13	rs1799750	G/G/G	0.26/0.52/0.22	0.28/0.47/0.25	0.13	0.45
*MMP* 12	14	rs652438	AA/AG/GG	0.90/0.10/0.00	0.90/0.09/0.00	0.34	0.87
	15	rs632009	CC/CT/TT	0.45/0.44/0.11	0.46/0.42/0.12	0.53	0.34
	16	rs11225442	GG/GA/AA	0.75/0.23/0.02	0.76/0.22/0.02	0.8	0.79
	17	rs28381675	AA/AG/GG	0.88/0.11/0.00	0.87/0.12/0.01	0.5	0.22
	18	rs2276109	AA/AG/GG	0.75/0.24/0.01	0.80/0.19/0.02	0.02	0.12
*MMP* 9	19	rs3918262	AA/AG/GG	0.66/0.31/0.03	0.63/0.32/0.05	0.12	0.15
	20	rs13969	CC/CA/AA	0.38/0.47/0.15	0.37/0.47/0.16	0.79	0.83
	21	rs2250889	CC/CG/GG	0.93/0.07/0.01	0.93/0.07/0.00	0.45	0.68
	22	rs3918256	AA/AG/GG	0.36/0.47/0.17	0.35/0.48/0.17	0.83	0.64
	23	rs17576	AA/AG/GG	0.43/0.45/0.12	0.42/0.45/0.13	0.62	0.58
	24	rs2274755	GG/GT/TT	0.71/0.26/0.02	0.73/0.25/0.02	0.69	0.79
	25	rs3918278	GG/GA/AA	0.96/0.04/0.00	0.95/0.05/0.00	0.46	0.13
	26	rs11697325	AA/AG/GG	0.39/0.46/0.15	0.37/0.47/0.16	0.64	0.64
Gene	SNP No.	Locus	Genotypes	Controls	COPD Severity IV*	Unadjusted P-value	Adjusted P-value**
*MMP12*	18	rs2276109	AA/AG/GG	0.75/0.24/0.01	0.83/0.15/0.02	0.008	0.03
Gene	SNP No.	Locus	Genotypes	Controls	COPD Severity III and IV*	Unadjusted P-value	Adjusted P-value**
*MMP12*	18	rs2276109	AA/AG/GG	0.75/0.24/0.01	0.81/0.17/0.01	0.007	0.08

*For GOLD classification severity III and IV, and severity IV, only SNPs with an unadjusted significant (p-value ≤ 0.01) genotypes difference between cases and controls are reported.
** P-values adjusted by logistic regression for age, sex, smoking and centre.

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