Skip to main content

Advertisement

Table 2 Phenotypic characteristics of the index patients.

From: Screening mutations in myosin binding protein C3 gene in a cohort of patients with Hypertrophic Cardiomyopathy

  Without mutation (n = 97) Mutation MyBPC3 (n = 20) Mutation MYH7 (n = 13) P (MyBPC3 vs MYH7) P (with vswithout mutation)
Age at diagnosis (years) 53 (16) 46 (16) 44 (19) 0.97 0.051
Age start follow up (years) 56 (16) 49(15) 50 (18) 0.86 0.049
Males 68% 55% 38% 0.46 0.054
Family history of HCM 23% 30% 62% 0.25 0.10
Family history of sudden death 16% 15% 31% 0.21 0.42
High blood pressure 43% 40% 23% 1 0.42
NYHA initial III-IV 10.5% 10% 8% 0.60 0.74
NYHA III-IV ever 38% 50% 46% 1 0,21
Angina 60% 70% 41% 0.45 0.68
Syncope 19% 15% 27% 0.64 1
Non-sustained ventricular tachycardia 25.3% 42.1% 40% 1 0.10
Abnormal blood pressure response 10.8% 31.6% 67% 0.9 0.030
Maximum left ventricular wall thickness(mm) 22 (6) 25 (7) 27 (8) 0.16 0.001
Wall thickness ≥ 30 mm 13% 15% 39% 0.95 0.09
Shortening fraction (%) 39 (10) 39 (11) 43 (10) 0.29 0.67
Left atrial diameter (mm) 45 (7) 50 (11) 50 (14) 0.79 0.038
Gradient ≥ 30 mmHg 29% 35% 31% 1 0.89
  1. Phenotypic characteristics of the index patients with mutations in MYH7, MyBPC3 and without mutations in those genes.
  2. HCM: hypertrophic cardiomyopathy; NYHA: New York Heart Asociation functional class