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Table 3 Triglyceride geometric means and 95% confidence intervals (mmol/L) by LPL, APOA5 and APOE genotypes.

From: Additive effects of LPL, APOA5 and APOEvariant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study

LPL-S447X1

447SS

1.15 (1.12-1.19)

APOA5-S19W4

19SS

1.11 (1.07-1.14)

 

447SX

1.02 (0.96-1.07)6

 

19SW

1.19 (1.10-1.28)

 

447XX

0.90 (0.75-1.10)

 

19WW

1.92 (0.94-3.96)9

LPL-HindIII1

H+H+

1.17 (1.13-1.22)

APOA5- (-1131T/C)5

-1131TT

1.11 (1.07-1.14)

 

H+H-

1.07 (1.03-1.11)7

 

-1131TC

1.24 (1.15-1.33)

 

H-H-

1.04 (0.97-1.13)8

 

-1131CC

1.39 (0.98-1.95)10

LPL-D9N2

9DD

1.12 (1.08-1.14)

APOE 1

ε2ε2

0.62 (0.35-1.10)

 

9DN

1.25 (1.07-1.47)

 

ε2 ε3

1.19 (1.03-1.29)

 

9NN

3.56

 

ε3ε3

1.08 (1.05-1.12)

LPL-N291S3

291NN

1.12 (1.08-1.14)

 

ε3ε4

1.22 (1.14-1.30)11

 

291NS

1.28 (1.11-1.46)

 

ε4ε4

1.50 (1.17-1.92)

 

291SS

-

 

ε2ε4

1.00 (0.80-1.26)

  1. Significant differences of ANOVA or the Student t test using log transformed variable (1 p < 0.001; 2 p = 0.043; 3 p = 0.080; 4 p = 0.005; 5 P = 0.012).
  2. Significant differences (p < 0.05) of post-hoc Bonferroni analysis: 6compared with 447SS; 7,8compared with H+H+; 9compared with 19SS and 19SW; one man TG>11.29 mmol/L; 10compared with -1131TT; 11compared with ε3ε3.