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Table 1 Demographic and clinical characteristics of the population analysed

From: Effect of TNF-α genetic variants and CCR5Δ32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards

Variable

Healthy controls

(n = 203)

EU

(n = 36)

HIV-1 TP#

(n = 109)

HIV-1 LTNP#

(n = 75)

pvalue

Male (%)

146 (72%)

22 (61%)

78 (71.5%)

50 (66.6%)

0.59*

Age (years)

(mean ± SD)

44.2 ± 9.9

46.7 ± 9.2

41.8 ± 8.9

41.6 ± 7.1

0.39**

Duration of HIV-1 infection

(mean ± SD)

-

-

6.2 ± 2.7

18.2 ± 1.6

< 0.0001

##, ***

Time span between documented infection and the onset of antiretroviral treatment

(mean ± SD)

-

-

4.8 ± 1.3

-

-

Plasma HIV-1 RNA (copies/ml)

(median and range)

-

-

11,808

(<50->750,000)

267

(<50-4,600)

< 0.0001

##, ****

CD4+ T-cell count (cells/μl)

(median and range)

-

-

478

(6-1404)

772

(503-2080)

< 0.0001 ##,****

Exposure to HIV-1

-

22 (61%)

61 (56%)

47 (62.7%)

0.64*

Parenteral

-

14 (39%)

39 (35.8%)

22 (29.3%)

0.53*

Sexual

-

-

9 (8.2%)

6 (8%)

0.82*

Other

     
  1. • EU: Individuals repeatedly exposed to HIV-1 but uninfected
  2. • HIV-1 TP: HIV-1-infected typical progressors
  3. • HIV-1 LTNP: HIV-1-infected long-term non-progressors
  4. • <50 was arbitrarily counted as 49
  5. # The studies made of HIV-1 TP and HIV-1 LTNP were cross-sectional and the viral load and CD4 cell counts are those of the date of selection. More than 90% of HIV-1 TP were under highly active antiretroviral therapy.
  6. ## p value stems from the comparison between HIV-1 TP and HIV-1 LTNP.
  7. * p value results of the χ2 test;
  8. ** p value results of the ANOVA test
  9. *** p value results of the Student T test
  10. **** p value results of the Mann-Whitney U test