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Figure 4 | BMC Medical Genetics

Figure 4

From: Essential role of the N-terminal region of TFII-I in viability and behavior

Figure 4

Neurobehavioral phenotype. A. Locomotor activity. A decrease in the vertical but not in horizontal locomotor activity measured in the actimetry box was observed in Gtf2i +/Δex2 mice (P = 0.03). B. Elevated Plus Maze. Higher anxiety level was manifested in the Gtf2i +/Δex2 indicated by the reduced percentage of entries in the open arms (P = 0.001) and in the time spent in open arms (P = 0.0089). C. Open Field. Histograms represent latency (in seconds) and the number of entries in central zone. D. Lit/dark box. Gtf2i +/Δex2 mice showed a higher anxiety level revealed by increased latency of the first entry (P = 0.01), the lower activity (P= 0.02) and the time spent into the lit compartment. E. Acoustic sensitivity. Enhanced sensitivity to an acute tone of 2800 Hz emitted at 65dB was observed in Gtf2i +/Δex2 mice demonstrated by a longer lasting freezing behavior (P = 0.01). Freezer response was similar between genotypes at 85, 105 and 125 dB confirming a plateau of response.

Gtf2i +/+, open; Gtf2i +/Δex2, grey squares. Each genotype groups are composed by males (n = 15). All values are expressed as mean ± s.d.

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