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Table 3 Association between rs9939609 and adiposity-related phenotypes

From: FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth

Variables

No.

Mean (95%CI)

χ2

(a/b)

P

(a/b)

Variance (%)

 

TT/AT/AA

TT

TA

AA

   

Weight(kg)

599/962/417

61.5(60.4-62.6)

62.0(61.0-63.0)

64.1(62.6-65.7)

4.97

0.03

0.20

BMI(kg/m2)

599/962/414

22.5(22.2-22.9)

22.8(22.5-23.1)

23.3(22.8-23.8)

6.38

0.01

0.24

Waist circumference (cm)

599/960/416

75.1(74.3-76.0)

75.5(74.8-76.2)

76.7(75.6-77.9)

4.39

0.04

0.16

Suprailiac (mm)

599/962/417

14.4(13.7-15.0)

14.4(13.9-15.0)

14.7(13.7-15.6)

1.07

0.30

-

Subscapular(mm)

598/961/417

14.1(13.5-14.7)

14.1(13.6-14.6)

14.7(13.9-15.5)

2.28

0.13

-

Triceps(mm)

599/961/417

15.7(15.2-16.3)

15.6(15.1-16.1)

15.8(15.0-16.6)

0.37

0.55

-

Sum of skinfold(mm)

599/960/417

44.8(43.2-46.5)

44.9(43.4-46.4)

46.0(43.7-48.5)

1.24

0.27

-

%BF

183/377/208

24.9(23.7-26.1)

25.1(24.2-25.9)

25.2(24.0-26.4)

0.09

0.77

-

VAT(cm3)

97/187/110

78.0(69.5-87.5)

82.1(75.2-89.8)

78.3(68.9-89.0)

0.00

0.98

-

SAAT (cm3)

97/187/109

627.1(539.1-729.6)

661.6(587.2-745.4)

673.5(568.4-798.0)

0.69

0.41

-

Fasting glucose(mmol/L)

213/391/211

5.07(5.02-5.13)

5.10(5.06-5.15)

5.10(5.05-5.16)

0.57/0.25

0.45/0.62

-

Fasting insulin (pmol/L)

208/387/205

94.4(88.6-100.6)

99.7(94.8-104.9)

94.8(86.5-103.9)

0.66/0.19

0.42/0.67

-

HOMA2-%B

206/385/205

140.1(134.8-145.7)

142.4(138.1-146.8)

139.3(132.5-146.4)

0.01/1.09

0.92/0.30

-

HOMA2-IR

206/385/205

1.7(1.6-1.9)

1.8(1.8-1.9)

1.8(1.6-1.9)

0.62/0.18

0.43/0.67

-

  1. BMI = body mass index; %BF = percentage of body fat; VAT = visceral adipose tissue; SAAT = subcutaneous abdominal adipose tissue; HOMA2-%B = homeostasis model assessment 2 β-cell function; HOMA2-IR = homeostasis model assessment 2 insulin resistance; P-values represent significance of the additive model (per-allele effect); Significant associations (P ≤ 0.05) are indicated in bold.
  2. All variables are presented as means and 95%CI adjusted for age, gender, ethnicity and cohort identifier.
  3. %variance = 100* (the difference of R-square value of the regression model additional with SNP compared to the base model).
  4. a: adjusted for age, ethnicity, gender, cohort identifier;
  5. b: adjusted for age, ethnicity, gender, cohort identifier and BMI.