Skip to main content

Advertisement

Table 3 Association between rs9939609 and adiposity-related phenotypes

From: FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth

Variables No. Mean (95%CI) χ2
(a/b)
P
(a/b)
Variance (%)
  TT/AT/AA TT TA AA    
Weight(kg) 599/962/417 61.5(60.4-62.6) 62.0(61.0-63.0) 64.1(62.6-65.7) 4.97 0.03 0.20
BMI(kg/m2) 599/962/414 22.5(22.2-22.9) 22.8(22.5-23.1) 23.3(22.8-23.8) 6.38 0.01 0.24
Waist circumference (cm) 599/960/416 75.1(74.3-76.0) 75.5(74.8-76.2) 76.7(75.6-77.9) 4.39 0.04 0.16
Suprailiac (mm) 599/962/417 14.4(13.7-15.0) 14.4(13.9-15.0) 14.7(13.7-15.6) 1.07 0.30 -
Subscapular(mm) 598/961/417 14.1(13.5-14.7) 14.1(13.6-14.6) 14.7(13.9-15.5) 2.28 0.13 -
Triceps(mm) 599/961/417 15.7(15.2-16.3) 15.6(15.1-16.1) 15.8(15.0-16.6) 0.37 0.55 -
Sum of skinfold(mm) 599/960/417 44.8(43.2-46.5) 44.9(43.4-46.4) 46.0(43.7-48.5) 1.24 0.27 -
%BF 183/377/208 24.9(23.7-26.1) 25.1(24.2-25.9) 25.2(24.0-26.4) 0.09 0.77 -
VAT(cm3) 97/187/110 78.0(69.5-87.5) 82.1(75.2-89.8) 78.3(68.9-89.0) 0.00 0.98 -
SAAT (cm3) 97/187/109 627.1(539.1-729.6) 661.6(587.2-745.4) 673.5(568.4-798.0) 0.69 0.41 -
Fasting glucose(mmol/L) 213/391/211 5.07(5.02-5.13) 5.10(5.06-5.15) 5.10(5.05-5.16) 0.57/0.25 0.45/0.62 -
Fasting insulin (pmol/L) 208/387/205 94.4(88.6-100.6) 99.7(94.8-104.9) 94.8(86.5-103.9) 0.66/0.19 0.42/0.67 -
HOMA2-%B 206/385/205 140.1(134.8-145.7) 142.4(138.1-146.8) 139.3(132.5-146.4) 0.01/1.09 0.92/0.30 -
HOMA2-IR 206/385/205 1.7(1.6-1.9) 1.8(1.8-1.9) 1.8(1.6-1.9) 0.62/0.18 0.43/0.67 -
  1. BMI = body mass index; %BF = percentage of body fat; VAT = visceral adipose tissue; SAAT = subcutaneous abdominal adipose tissue; HOMA2-%B = homeostasis model assessment 2 β-cell function; HOMA2-IR = homeostasis model assessment 2 insulin resistance; P-values represent significance of the additive model (per-allele effect); Significant associations (P ≤ 0.05) are indicated in bold.
  2. All variables are presented as means and 95%CI adjusted for age, gender, ethnicity and cohort identifier.
  3. %variance = 100* (the difference of R-square value of the regression model additional with SNP compared to the base model).
  4. a: adjusted for age, ethnicity, gender, cohort identifier;
  5. b: adjusted for age, ethnicity, gender, cohort identifier and BMI.