Table 3 Epistasis effects for TC and HDL-C with the significance of suggestive linkage.

TC

rs4437278

4

12488199

U6 ^a (174 kb)

0.15

rs705169

10

125285443

GRP26(140 kb)

0.49

4.49E-10

AA

5.93E-12

0.249 ± 0.036

rs4738150

8

72607907

U8 ^a (120 kb)

0.40

rs16918936

9

33009027

APTX, LOC646808

0.04

4.68E-13

AD

1.29E-12

-1.348 ± 0.188

HDL-C

rs10476539

5

91991628

AC026781.5 ^a (62 kb)

0.18

rs2392885

8

129003117

PVT1 ^a

0.28

2.63E-10

AA

2.99E-12

-0.269 ± 0.037

rs4706271

6

70390132

LMBRD1(intron14)

0.41

rs6581219

12

59213144

LRIG3(53 kb)

0.42

7.67E-11

DD

5.72E-13

-0.412 ± 0.056

rs7741758

6

70412380

LMBRD1(intron9)

0.41

rs6581219

12

59213144

LRIG3(53 kb)

0.42

5.73E-10

DD

4.60E-12

-0.388 ± 0.054

rs9346333

6

70426479

LMBRD1(intron8)

0.41

rs6581219

12

59213144

LRIG3(53 kb)

0.42

1.39E-10

DD

1.16E-12

-0.398 ± 0.054

rs9351772

6

70428200

LMBRD1(intron8)

0.41

rs6581219

12

59213144

LRIG3(53 kb)

0.42

5.38E-10

DD

4.25E-12

-0.390 ± 0.055

rs7762400

6

70445634

LMBRD1(intron7)

0.41

rs6581219

12

59213144

LRIG3(53 kb)

0.42

4.41E-10

DD

3.52E-12

-0.388 ± 0.054

rs9294851

6

70457629

LMBRD1(intron5)

0.41

rs6581219

12

59213144

LRIG3(53 kb)

0.42

2.83E-10

DD

2.22E-12

-0.392 ± 0.054

rs9354890

6

70504296

LMBRD1(intron1)

0.41

rs6581219

12

59213144

LRIG3(53 kb)

0.42

5.54E-10

DD

4.18E-12

-0.388 ± 0.054

rs9364063

6

70514750

LMBRD1(8 kb)

0.41

rs6581219

12

59213144

LRIG3(53 kb)

0.42

4.65E-10

DD

4.46E-12

-0.386 ± 0.054

rs2787520

6

106821428

ATG5(48 kb)

0.35

rs7236739

18

20800715

CABLES1(intron4)

0.31

2.98E-10

AA

2.48E-12

-0.211 ± 0.029

rs2842169

10

128330713

AL583860.7 ^a (85 kb)

0.10

rs4756344

11

36765284

C11orf74(84 kb)

0.26

3.56E-10

AA

3.73E-12

0.348 ± 0.049

rs17623128

16

77630108

AC092724.2 ^a (114 kb)

0.33

rs6506699

18

9775566

RAB31

0.49

4.65E-10

DD

2.78E-12

-0.449 ± 0.062

rs12596869

16

77630380

AC092724.2 ^a (114 kb)

0.33

rs6506699

18

9775566

RAB31

0.49

3.81E-10

DD

2.30E-12

-0.451 ± 0.062