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Table 1 Single-locus SNP effects for TC with genome control (GC) adjusted P < 7.2 × 10-8.

From: Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham Heart Study data

       Effect Type & P value  
SNP Chr Position Gene Region Reported SNP effect MAF Genotype Additive Effect Size
rs4970834 1 109814880 CELSR2 a (intron 28) Non-HDL-C [57] 0.18 1.10E-08 1.75E-09 0.146 ± 0.023
     TC [8]     
rs599839 1 109822166 10 bases downstream LDL-C [6, 7, 9, 10] 0.22 8.72E-14 2.46E-14 0.174 ± 0.021
    PSRC1 a Non-HDL-C [5]     
rs4245791 2 44074431 ABCG8 (intron 3)   0.32 1.82E-07 3.33E-08 -0.127 ± 0.021
rs6730157 2 135907088 RAB3GAP1 (intron 17) LDL-C: P = 0.018 [2]b 0.45 8.51E-08 2.16E-08 0.113 ± 0.019
rs12465802 2 136381348 R3HDM1 (intron 7) LDL-C: P = 0.022 [2]b 0.44 2.63E-08 7.98E-09 0.117 ± 0.019
rs4954280 2 136420690 R3HDM1 (intron18) LDL-C: P = 0.007 [2]b 0.33 1.49E-07 5.87E-08 0.114 ± 0.02
rs2322660 2 136557319 LCT (intron 12) LDL-C: P = 0.055 [2]b 0.35 2.42E-08 7.08E-09 -0.120 ± 0.019
     TC: P = 0.003-0.005 [17]     
     LDL-C: P = 0.002-0.0005 [17]     
rs309180 2 136614255 MCM6 (intron 11) LDL-C: P = 0.057 [2]b 0.36 2.43E-08 8.39E-09 -0.119 ± 0.019
rs632632 2 136638216 4.2 kb upstream MCM6 LDL-C: P = 0.216 [2]b 0.36 2.50E-08 1.03E-08 -0.118 ± 0.019
  1. a This gene was reported to be associated with TC [1].
  2. b Available at http://www.sph.umich.edu/csg/abecasis/public/lipids2008/