BMC Medical Genetics

Table 4 Association results for age at onset

From: Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease

	Age At Onset (cases)			Age At Onset (sibship¹)
Allele	Carriers	Non-carriers	p	Carriers	Non-carriers	p
1719A	61.7	63.2	0.52	61.8	64.4	0.16
4580A	61.8	60.4	0.61	62	61.1	0.76
7028C	61.2	62.4	0.21	61.5	62.5	0.28
8251A	61.9	59.2	0.20	62.1	59.5	0.20
9055A	62.0	59.8	0.22	62.1	60.2	0.26
10398G	60.3	62.2	0.11	60.6	62.3	0.15
10400T	57.7	61.8	0.48	60.2	62.0	0.75
12308G	60.2	62.2	0.08	59.8	62.5	0.01
13368A	61.6	63.7	0.17	61.7	63.8	0.17
13708A	61.8	62.0	0.86	62.0	61.9	0.98
16391A	61.9	58.9	0.39	62.0	58.3	0.26
H	62.2	61.5	0.49	62.4	61.6	0.41
I	59.6	61.8	0.54	59.3	62.0	0.45
J	61.4	61.8	0.80	61.7	62.0	0.89
K	59.6	62.0	0.18	60.0	62.1	0.22
M	57.7	61.8	0.48	60.2	62.0	0.75
T	63.7	61.6	0.20	63.6	61.8	0.23
U	60.4	62.0	0.26	59.4	62.3	0.03
V	60.9	61.8	0.77	61.3	62.0	0.83
W	60.2	61.8	0.67	58.9	62.0	0.38
X	65.2	61.7	0.45	67.1	61.8	0.06
Other	62.6	61.7	0.63	63.3	61.8	0.35
IJK vs. HMTUVWX	60.5	62.1	0.19	60.8	62.2	0.23
JTUK vs. HIMVWX	61.1	62.1	0.35	60.8	62.5	0.09
JTIWX vs. HKMUV	62.5	61.6	0.41	62.7	61.7	0.34

¹ Since all siblings share the same mitochondrial SNP alleles and therefore haplogroups, testing for association with the mean age at onset of all affected siblings in a nuclear family is a valid and more powerful test. The number of affected siblings in a family ranged from 1 to 5.

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