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Table 3 Allele and genotype frequencies of SNPs in ADPRT1, AKR1B1, RAGE, GFPT2, PAI and their association status with diabetic CRI, and the power of sample size to detect association at 5% significance level.

From: Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes

SNPs

Allele frequency

Genotype frequency

Association

Power (G %)

 

DM

CRI

DM

CRI

Allele

Genotype

 
 

(n = 225)

(n = 196)

 

(n = 225)

(n = 196)

(df = 1)

(df = 2)

 

ADPRT1

T>C

T = 0.91

C = 0.09

T = 0.925

C = 0.075

TT = 0.87

TC = 0.12

CC = 0.01

TT = 0.83

TC = 0.16

CC = 0.01

χ2 = 0.21;

P = 0.64,

P* = 0.13

χ2 = 1.61;

P = 0.45;

P* = 0.11

12

ADPRT1

A>G

A = 0.91

G = 0.09

A = 0.92

G = 0.08

AA = 0.83

AG = 0.17

GG = 0.00

AA = 0.84

AG = 0.14

GG = 0.02

χ2 = 0.07;

P = 0.79;

P* = 0.13

χ2 = 3.3;

P = 0.19;

P* = 0.14

8

AKR1B1

G>C

G = 0.93

C = 0.07

G = 0.93

C = 0.07

GG = 0.86

GC = 0.14

CC = 0.00

GG = 0.89

GC = 0.11

CC = 0.00

χ2 = 0.88;

P = 0.35;

P* = 0.15

χ2 = 0.94;

P = 0.33

(df = 1);

P* = 0.14

0

RAGE

-429T>C

T = 0.87

C = 0.13

T = 0.88

C = 0.12

TT = 0.77

TC = 0.22

CC = 0.01

TT = 0.81

TC = 0.14

CC = 0.05

χ2 = 0.04;

P = 0.84;

P* = 0.11

χ 2 = 8.68;

P = 0.013;

P* = 0.015

OR = 9.03, 95% CI = (1.09<OR<74.26)

7

RAGE

63 bp ins/del

Ins = 0.96

Del = 0.04

Ins = 0.97

Del = 0.03

Ins/Ins = 0.95

Ins/Del = 0.05

Del/Del = 0.00

Ins/Ins = 0.91

Ins/Del = 0.09

Del/Del = 0.00

χ2 = 0.26;

P = 0.60;

P* = 0.15

P* = 0.06

12

GFPT2

C>T

C = 0.78

T = 0.22

C = 0.72

T = 0.28

CC = 0.50

CT = 0.45

TT = 0.05

CC = 0.60

CT = 0.37

TT = 0.03

χ 2 = 3.92;

P = 0.047;

P* = 0.03

OR = 1.38, 95% CI = (1.02<OR<1.98)

χ2 = 4.5;

P = 0.11;

P* = 0.04

51

PAI-1 4G/5G (del/ins)

4G = 0.52

5G = 0.48

4G = 0.49

5G = 0.51

4G4G = 0.23

4G5G = 0.52

5G5G = 0.25

4G4G = 0.29

4G5G = 0.46

5G5G = 0.25

χ2 = 0.84;

P = 0.36;

P* = 0.06

χ2 = 2.5;

P* = 0.29

14

  1. P:P value for Pearson's chi-square test
  2. P*: Fisher's exact P value.