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Table 3 SNPs with the highest evidence of association in the region upstream the SYT1 gene.#

From: A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2with serum creatinine level

Study

name

position

Genotype (Ref. All.)

Ref. All. Freq.

n

Beta*

SE

p value**

EUROSPAN

rs11838060

77997790

G/T (T)

0.14

3163

-0.0696

0.0312

0.0258

EUROSPAN

rs10506807

78005428

C/T (C)

0.13

4000

-0.1141

0.0287

7.0 × 10-5

EUROSPAN

rs12300068

78005502

A/G (A)

0.13

3997

-0.1158

0.0288

5.7 × 10-5

EUROSPAN

rs7972593

78013149

C/T (T)

0.12

3989

-0.0978

0.0300

1.1 × 10-3

EUROSPAN

rs11112829

78029267

C/T (C)

0.13

4000

-0.1135

0.0287

7.5 × 10-5

POPGEN

rs12312807

77957336

A/G (A)

0.11

1139

0.1480

0.0539

6.1 × 10-3

POPGEN

rs1527119

77964145

G/T (G)

0.11

1139

0.1471

0.0539

6.4 × 10-3

POPGEN

rs1033196

77966968

C/T (T)

0.14

1128

0.1320

0.0479

5.8 × 10-3

POPGEN

rs2950383

77973538

A/G (A)

0.37

1103

-0.1553

0.0359

2.0 × 10-5

POPGEN

rs1356022

77974533

C/T (C)

0.14

1140

0.1300

0.0475

6.2 × 10-3

POPGEN

rs12317960

77977824

C/T (T)

0.14

1140

0.1249

0.0474

8.5 × 10-3

POPGEN

rs10506806

77979113

C/T (T)

0.31

1120

0.1012

0.0362

5.1 × 10-3

POPGEN

rs11610381

77979918

C/T (C)

0.14

1134

0.1321

0.0476

5.5 × 10-3

POPGEN

rs7971081

77980051

C/T (C)

0.14

1140

0.1296

0.0474

6.3 × 10-3

  1. # association models were adjusted for age and sex; *in standard deviations; **p value: for EUROSPAN, the p value refers to the meta-analysis of the five individual GWA studies, for popgen, the p value is from the linear regression analysis (for details, see Methods).