Table 2 Nominally significant (P < 0.05) single-SNP genotypic tests of association with T2D age at diagnosis, ESRD age at onset, BMI on dialysis, and duration of T2D to ESRD onset.

IL6

Rs2069849

G/A

0.15

59.0 ± 10.5 (419)

59.8 ± 10.4 (140)

53.7 ± 10.4 (16)

0.896

0.581

0.040 (0.013) ^a

IL6

rs1554606

C/A

0.34

20.2 ± 13.7 (255)

19.7 ± 14.7 (245)

15.8 ± 13.0 (68)

0.247

0.052

0.007 (0.006) ^a

GCK1

rs2908296

C/A

0.35

41.6 ± 11.0 (235)

42.8 ± 12.2 (277)

38.0 ± 10.3 (63)

0.733

0.313

0.007 (0.014) ^b

GCK1

rs12673242

A/G

0.37

41.3 ± 11.4 (236)

43.2 ± 11.9 (258)

39.0 ± 11.2 (81)

0.38

0.606

0.023 (0.032) ^b

GCK1

rs2908296

C/A

0.35

59.2 ± 10.0 (235)

59.4 ± 11.2 (277)

56.1 ± 8.7 (63)

0.632

0.157

0.027 (0.133) ^a

GCK1

rs2971676

G/A

0.24

59.4 ± 10.4 (328)

59.0 ± 10.8 (217)

54.4 ± 8.8 (30)

0.328

0.092

0.02 (0.035) ^a

GCK1

rs2971675

C/A

0.23

59.5 ± 10.5 (338)

58.7 ± 10.8 (210)

54.5 ± 8.4 (27)

0.2

0.065

0.033 (0.029) ^a

GCK1

rs730497

G/A

0.2

58.9 ± 10.4 (367)

60.0 ± 10.6 (180)

51.5 ± 8.6 (25)

0.989

0.206

0.0004 (0.0006) ^a

GCK1

rs2908289

G/A

0.27

58.5 ± 10.5 (315)

60.6 ± 10.7 (211)

55.1 ± 8.8 (49)

0.223

0.827

0.008 (0.129)^a

IGFBP1

rs1908751

C/T

0.33

29.8 ± 7.3 (254)

29.2 ± 6.7 (243)

31.6 ± 7.1 (60)

0.838

0.436

0.043 (0.067)^a

IGFBP3

rs10255707

G/A

0.04

29.9 ± 7.1 (511)

27.3 ± 5.4 (33)

23.5 ± 7.4 (2)

0.022 (0.120)^a

-

-

IGFBP3

rs3110697

G/A

0.35

21.3 ± 15.7 (234)

18.5 ± 12.7 (270)

19.8 ± 14.2 (63)

0.027 (0.067)^a

0.055

0.586