Skip to main content

Advertisement

Table 2 Nominally significant (P < 0.05) single-SNP genotypic tests of association with T2D age at diagnosis, ESRD age at onset, BMI on dialysis, and duration of T2D to ESRD onset.

From: Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy

Phenotype Gene Marker Major/Minor alleles MAF Case 1/1 Mean ± SD (n) 1/2 Mean ± SD (n) 2/2 Mean ± SD (n) Dominant P-value Additive P-value Recessive P-value
ESRD age IL6 Rs2069849 G/A 0.15 59.0 ± 10.5 (419) 59.8 ± 10.4 (140) 53.7 ± 10.4 (16) 0.896 0.581 0.040 (0.013) a
Duration of T2D to ESRD IL6 rs1554606 C/A 0.34 20.2 ± 13.7 (255) 19.7 ± 14.7 (245) 15.8 ± 13.0 (68) 0.247 0.052 0.007 (0.006) a
T2D age GCK1 rs2908296 C/A 0.35 41.6 ± 11.0 (235) 42.8 ± 12.2 (277) 38.0 ± 10.3 (63) 0.733 0.313 0.007 (0.014) b
T2D age GCK1 rs12673242 A/G 0.37 41.3 ± 11.4 (236) 43.2 ± 11.9 (258) 39.0 ± 11.2 (81) 0.38 0.606 0.023 (0.032) b
ESRD age GCK1 rs2908296 C/A 0.35 59.2 ± 10.0 (235) 59.4 ± 11.2 (277) 56.1 ± 8.7 (63) 0.632 0.157 0.027 (0.133) a
ESRD age GCK1 rs2971676 G/A 0.24 59.4 ± 10.4 (328) 59.0 ± 10.8 (217) 54.4 ± 8.8 (30) 0.328 0.092 0.02 (0.035) a
ESRD age GCK1 rs2971675 C/A 0.23 59.5 ± 10.5 (338) 58.7 ± 10.8 (210) 54.5 ± 8.4 (27) 0.2 0.065 0.033 (0.029) a
ESRD age GCK1 rs730497 G/A 0.2 58.9 ± 10.4 (367) 60.0 ± 10.6 (180) 51.5 ± 8.6 (25) 0.989 0.206 0.0004 (0.0006) a
ESRD age GCK1 rs2908289 G/A 0.27 58.5 ± 10.5 (315) 60.6 ± 10.7 (211) 55.1 ± 8.8 (49) 0.223 0.827 0.008 (0.129)a
BMI IGFBP1 rs1908751 C/T 0.33 29.8 ± 7.3 (254) 29.2 ± 6.7 (243) 31.6 ± 7.1 (60) 0.838 0.436 0.043 (0.067)a
BMI IGFBP3 rs10255707 G/A 0.04 29.9 ± 7.1 (511) 27.3 ± 5.4 (33) 23.5 ± 7.4 (2) 0.022 (0.120)a - -
Duration of T2D to ESRD IGFBP3 rs3110697 G/A 0.35 21.3 ± 15.7 (234) 18.5 ± 12.7 (270) 19.8 ± 14.2 (63) 0.027 (0.067)a 0.055 0.586
  1. Test models refer to the minor allele. *Only the dominant model was considered where the minor allele homozygote count was <10. Bold: P-values < 0.05. Unadjusted P values without parentheses and P values with parentheses adjusted for aT2D age- and bBMI.