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Table 1 Genotypes and TDT results of the analysed SNPs in FAAH in the obesity trios

From: Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity

SNP1

Position2

Location

exchange

N3

Genotypes (frequency %)4

Allele frequ.%5

Transm. rate6

TDT p-value

    

GG 243 (0.478)

G: 0.68

  
  

putative

 

GA 209 (0.412)

   

rs932816

g.-272G/A

promoter

508

AA 56 (0.110)

A: 0.32

0.53 (A)

0.14

  

Exon 3,

 

CC 248 (0.690)

C: 0.83

  
    

CA 101 (0.282)

   

rs324420

c.385C/A

Pro129Thr

359

AA 10 (0.028)

A: 0.17

0.44 (A)

0.06

  

Exon 7

 

GG 258 (0.730)

G: 0.85

  
    

GA 87 (0.247)

   

rs324419

c.895A/G

Cys299Cys

353

AA 8 (0.023)

A: 0.15

0.44 (A)

0.08

    

GG 351 (0.978)

G: 0.99

  
    

GA 8 (0.022)

   

rs873978

IVS7-228G/A

Intron 7

359

AA 0 (0.000)

A: 0.01

0.88 (A)

0.10

    

GG 214 (0.610)

G: 0.77

  
    

GT 113 (0.322)

   

rs2295632

*45G/T

3' region

351

TT 24 (0.068)

T: 0.23

0.44 (T)

0.05

  1. 1 all SNPs were tested for Hardy-Weinberg equilibrium (p ≥ 0.05); 2 numbers are given according to Dunnen and Antonarakis 2001 Hum Genet 109:121-124 [33]; 3 number of obesity trios; 4 genotype frequencies in the index patients of the obesity trios; 5 allele frequencies in the index patients of the obesity trios. These are very similar to the allele frequencies reported for the European population in the dbSNP database http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/SNP/; 6 transmission rate of minor allele
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