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Table 2 Haplotypic analysis at the four WWOX regions selected in the genotypic analysis

From: WWOX gene is associated with HDL cholesterol and triglyceride levels

 

HAPLOTYPE

FREQ.

TGs

HDL

TGs/HDL

REGION 1

CTTCCTCCCGCGCAGA

0.14

(-ref)

(-ref)

(-ref)

 

TTCGATCTTCGATGGG

0.12

11.44

(0.09; 22.80)

0.38

(-2.03; 2.78)

0.28

(-0.05; 0.59)

 

CCTGAGTTTCGACAGG

0.11

10.05

(-1.96; 22.10)

-2.14

(-4.68; 0.41)

0.34

(0.01; 0.68)

 

CCTGAGTTTCGATGGG

0.17

15.32

(5.27; 25.40)

0.41

(-1.72; 2.54)

0.39

(0.10; 0.67)

 

CTCGATTTTCCGCACA

0.09

2.85

(-10.30; 16.00)

0.60

(-2.18; 3.38)

0.003

(-0.37; 0.38)

 

CCTGAGTTTCCACAGG

0.07

7.82

(-6.54; 22.20)

4.24

(1.2; 7.28)

0.03

(-0.38; 0.43)

 

CTTCCTCTTCCATAGG

0.05

10.54

(-5.77; 27.00)

2.73

(-0.75; 6.19)

0.23

(-0.23; 0.69)

 

CTTCCTCTTCCGCACA

0.07

-15.76

(-30.20;-1.29)

2.04

(-1.02; 5.11)

-0.42

(-0.83; -0.01)

 

GLOBAL HAPLOTYPIC EFFECT

F = 3.13

p = 0.003

F = 2.435

p = 0.018

F = 2.836

p = 0.006

REGION 2

TGACAAGACATG

0.09

(-ref)

(-ref)

(-ref)

 

CATAAAGAGGTA

0.07

1.50

(-13.50; 16.50)

-2.62

(-5.79; 0.56)

0.09

(-0.33; 0.52)

 

CATACGCGGGTA

0.52

12.54

(3.34; 21.70)

-2.43

(-4.37; -0.48)

0.41

(0.15; 0.66)

 

CATACGCGGGCA

0.19

8.36

(-2.86; 19.60)

-3.33

(-5.7; -0.95)

0.31

(-0.01; 0.62)

 

CATACGCGCATA

0.05

20.08

(3.23; 36.90)

-1.81

(-5.37; 1.76)

0.67

(0.20; 1.15)

 

GLOBAL HAPLOTYPIC EFFECT

F = 2.72

p = 0.028

F = 2.17

p = 0.070

F = 3.50

p = 0.007

REGION 3

GACGCTGCACTAGCGATCATTAGTACCAGACATGACAGCCCGC

0.28

(-ref)

(-ref)

(-ref)

 

ATGTTCAGAGTAAGCGAGGTCACCGCGGCGGCCAGGGATATAT

0.31

-3.62

(-11.30; 4.04)

0.72

(-0.89; 2.34)

-0.13

(-0.34; 0.09)

 

GAGGTTGGGCAGGCCATCACTGCTACCAGACCTGAGAACACAC

0.07

-12.22

(-25.10; 0.67)

-2.07

(-4.78; 0.65)

-0.26

(-0.62; 0.11)

 

GLOBAL HAPLOTYPIC EFFECT

F = 1.89

p = 0.151

F = 1.81

p = 0.165

F = 1.35

p = 0.261

REGION 4

GCTCTCCCGAAGGCCAGAGAACACCTAGACGATT

0.12

(-ref)

(-ref)

(-ref)

 

GCTCTCCCTAGGGTAGAAAGCATTCCCCAAGATT

0.06

-11.44

(-27.80; 4.88)

0.54

(-2.93; 4.02)

-0.32

(-0.79; 0.14)

 

GTACGAGCGAAGGCCAGAGAACACCTAGACGATT

0.18

6.45

(-3.59; 16.50)

-1.09

(-3.24; 1.04)

0.20

(-0.09; 0.48)

 

GTACGAGCTAGGGTAGAAAGCATTCCCCAAGATT

0.18

-6.28

(-15.4; 2.84)

-0.30

(-2.24; 1.64)

-0.09

(-0.35; 0.17)

 

GTACGAGCGGGAACCGGGAAACACCCACACAATT

0.07

11.58

(-1.97; 25.10)

-1.02

(-3.90; 1.87)

0.28

(-0.11; 0.66)

 

GLOBAL HAPLOTYPIC EFFECT

F = 2.61

p = 0.0347

F = 0.43

p = 0.786

F = 1.99

p = 0.0939

  1. Region 1 (Chr.16: 76,689,775-76,716,533 bp): rs10220947, rs4887935, rs7192129, rs12931172, rs8045450, rs2287973, rs2287972, rs16947127, rs16947129, rs12917833, rs10492874, rs11645006, rs2042356, rs1079569, rs12920698, rs1076514.
  2. Region 2 (Chr.16: 77,433,428 - 77,441,867 bp): rs7405423, rs7405283, rs9922613, rs4888865, rs6420411, rs1543296, rs7498176, rs7501409, rs12447303, rs7190122, rs11643930, rs4145518.
  3. Region 3 (Chr.16: 77,538,855-77,563,088 bp): rs11643794, rs11642227, rs10871357, rs4888887, rs1995549, rs8063186, rs11648482, rs7205567, rs16949032, rs17709129, rs17709147, rs17635945, rs11150119, rs9319530, rs13334115, rs10871358, rs12596756, rs12925319, rs16949036, rs12447067, rs9941223, rs7189021, rs17636170, rs8052880, rs4600477, rs4888888, rs4888889, rs8052893, rs11150120, rs13339083, rs4888892, rs13330742, rs16944152, rs2047927, rs5024396, rs17636262, rs2062900, rs8057659, rs12716865, rs1467067, rs11860206, rs1110891, rs1110894.
  4. Region 4 (Chr.16: 77,605,536 - 77,620,657 bp): rs12598471, rs2550725, rs1862841, rs16949214, rs2550724, rs12447246, rs2550723, rs16949222, rs2113305, rs7185820, rs8064141, rs16949238, rs16949240, rs2656653, rs2550718, rs2550717, rs2550716, rs16949251, rs8047597, rs2550711, rs8047300, rs2550710, rs7199119, rs1808447, rs905781, rs8053936, rs2550702, rs2550701, rs2656649, rs11645630, rs16949276, rs2656647, rs2656646, rs2550698.
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