Figure 6

GeneGo network, including nicotine. The GeneGo network connects the overlapping candidates using the smallest number of nodes at the highest level of confidence for the edges. Nicotine and the nodes required to connect nicotine to the network have been added. Overlapping candidate genes (COMT, Dopamine transporter, and SERT) are shown as red, green, and blue circles. Other nodes are coded by the type of protein coded by the gene (e.g. kinases, transporters, etc.). Edges are labeled for direction of effect, where appropriate, and are green for activation or red for repression.