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Table 4 Summary of the results obtained for models selected in the analysis of heterogeneity in variance components by age

From: Evaluating gene by sex and age interactions on cardiovascular risk factors in Brazilian families

  

No Heterogeneity

 

Heterogeneity in Variance Components by Groups of Age

Traits

Covariates

Polygenic

heritability

estimates

Estimates of polygenic

and environmental

variances

Selected model

Polygenic heritability

estimates

Estimates of polygenic and

environmental variances

      

Young

Old

Young

Old

  

h2(s.d.)

σ g 2

σ e 2

variance with heterogeneity

h y 2

h o 2

σ g , y 2

σ e , y 2

σ g , o 2

σ e , o 2

ln(SBP)

No

Age

Sex, Age

0.1412 (0.034)

0.2647 (0.041)

0.2685 (0.041)

0.1783

0.2509

0.2499

1.0841

0.6969

0.6808

genetic

genetic

genetic

0.0016

0.0099

0.0117

0.1512

0.2008

0.2155

0.0014

0.0065

0.0067

0.8477

0.6468

0.5639

0.1510

0.1625

0.1549

0.8477

0.6468

0.5639

ln(DBP)

No

Age

Sex, Age

0.1484 (0.036)

0.2306 (0.041)

0.2305 (0.041)

0.1645

0.2242

0.2241

0.9436

0.7480

0.7479

genetic

genetic

genetic

0.0420

0.0252

0.0330

0.1801

0.1625

0.1938

0.0399

0.0244

0.0254

0.9100

0.9440

0.7438

0.1999

0.1832

0.1788

0.9100

0.9440

0.7438

ln(GLU)

Δ No

Δ Age

Δ Sex, Age

0.3401 (0.046)

0.3571 (0.048)

0.3570 (0.048)

0.3250

0.3137

0.3136

0.6305

0.5647

0.5648

environmental

environmental

environmental

0.9554

0.9324

0.9330

0.5058

0.5093

0.5095

0.3346

0.3163

0.3163

0.0156

0.0229

0.0227

0.3346

0.3163

0.3163

0.3269

0.3047

0.3045

ln(LDL)

Δ No

Δ Age

Δ Sex, Age

0.2956 (0.049)

0.2983 (0.050)

0.2966 (0.050)

0.2903

0.2796

0.2751

0.6918

0.6575

0.6522

no heterogeneity

no heterogeneity

no heterogeneity

0.2956

0.2983

0.2966

0.2956

0.2983

0.2966

0.2903

0.2796

0.2751

0.6918

0.6575

0.6522

0.2903

0.2796

0.2751

0.6918

0.6575

0.6522

ln(HDL)

Δ No

Δ Age

Δ Sex, Age

0.3209 (0.047)

0.3323 (0.048)

0.3323 (0.049)

0.4134

0.4245

0.4207

0.8747

0.8529

0.8452

environmental

environmental

environmental

0.4547

0.4467

0.4546

0.3652

0.3729

0.3755

0.4276

0.4357

0.4325

0.5126

0.5395

0.5188

0.4276

0.4357

0.4325

0.7430

0.7327

0.7193

ln(TRG)

No

Age

Sex, Age

0.2590 (0.044)

0.2874 (0.047)

0.2863 (0.047)

0.2338

0.2339

0.2328

0.6687

0.5799

0.5803

genetic

genetic

genetic

0.0843

0.1263

0.0268

0.2680

0.2385

0.2600

0.0633

0.0826

0.0169

0.6875

0.5714

0.6130

0.2518

0.1790

0.2154

0.6875

0.5714

0.6130

  1. SBP = systolic blood pressure, DBP = diastolic blood pressure, GLU = fasting glucose, LDL = LDL-cholesterol, HDL = HDL-cholesterol. TRG = triglycerides, Δ = the t-dist procedure used in SOLAR, σ g 2 and σ e 2 are estimates of polygenic and environmental variances, σ g , y 2 and σ g , o 2 are estimates of young and old polygenic variances, σ e , y 2 and σ e , o 2 are estimates of young and old environmental variances. Significance level of 5% was used in the selection procedure of the best model.