From: Evaluating gene by sex and age interactions on cardiovascular risk factors in Brazilian families
No Heterogeneity | Heterogeneity in Variance Components by Groups of Age | ||||||||||
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Traits | Covariates | Polygenic heritability estimates | Estimates of polygenic and environmental variances | Selected model | Polygenic heritability estimates | Estimates of polygenic and environmental variances | |||||
Young | Old | Young | Old | ||||||||
h2(s.d.) |
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ln(SBP) | No Age Sex, Age | 0.1412 (0.034) 0.2647 (0.041) 0.2685 (0.041) | 0.1783 0.2509 0.2499 | 1.0841 0.6969 0.6808 | genetic genetic genetic | 0.0016 0.0099 0.0117 | 0.1512 0.2008 0.2155 | 0.0014 0.0065 0.0067 | 0.8477 0.6468 0.5639 | 0.1510 0.1625 0.1549 | 0.8477 0.6468 0.5639 |
ln(DBP) | No Age Sex, Age | 0.1484 (0.036) 0.2306 (0.041) 0.2305 (0.041) | 0.1645 0.2242 0.2241 | 0.9436 0.7480 0.7479 | genetic genetic genetic | 0.0420 0.0252 0.0330 | 0.1801 0.1625 0.1938 | 0.0399 0.0244 0.0254 | 0.9100 0.9440 0.7438 | 0.1999 0.1832 0.1788 | 0.9100 0.9440 0.7438 |
ln(GLU) | Δ No Δ Age Δ Sex, Age | 0.3401 (0.046) 0.3571 (0.048) 0.3570 (0.048) | 0.3250 0.3137 0.3136 | 0.6305 0.5647 0.5648 | environmental environmental environmental | 0.9554 0.9324 0.9330 | 0.5058 0.5093 0.5095 | 0.3346 0.3163 0.3163 | 0.0156 0.0229 0.0227 | 0.3346 0.3163 0.3163 | 0.3269 0.3047 0.3045 |
ln(LDL) | Δ No Δ Age Δ Sex, Age | 0.2956 (0.049) 0.2983 (0.050) 0.2966 (0.050) | 0.2903 0.2796 0.2751 | 0.6918 0.6575 0.6522 | no heterogeneity no heterogeneity no heterogeneity | 0.2956 0.2983 0.2966 | 0.2956 0.2983 0.2966 | 0.2903 0.2796 0.2751 | 0.6918 0.6575 0.6522 | 0.2903 0.2796 0.2751 | 0.6918 0.6575 0.6522 |
ln(HDL) | Δ No Δ Age Δ Sex, Age | 0.3209 (0.047) 0.3323 (0.048) 0.3323 (0.049) | 0.4134 0.4245 0.4207 | 0.8747 0.8529 0.8452 | environmental environmental environmental | 0.4547 0.4467 0.4546 | 0.3652 0.3729 0.3755 | 0.4276 0.4357 0.4325 | 0.5126 0.5395 0.5188 | 0.4276 0.4357 0.4325 | 0.7430 0.7327 0.7193 |
ln(TRG) | No Age Sex, Age | 0.2590 (0.044) 0.2874 (0.047) 0.2863 (0.047) | 0.2338 0.2339 0.2328 | 0.6687 0.5799 0.5803 | genetic genetic genetic | 0.0843 0.1263 0.0268 | 0.2680 0.2385 0.2600 | 0.0633 0.0826 0.0169 | 0.6875 0.5714 0.6130 | 0.2518 0.1790 0.2154 | 0.6875 0.5714 0.6130 |