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Table 1 Statistics of cancer genes with not less than 100 mutations.

From: Important role of indels in somatic mutations of human cancer genes

Gene name

Total mutation number

Number of base substitutionsa

Number of indels

S/I ratio

Category of S-I linkage

Gene type

APC

808

266 (11, 255)

542

0.49

Apparent

Tumor suppressor gene

PTEN

769

407 (19, 388)

362

1.12

Insignificant

Tumor suppressor gene

VHL

756

296 (38, 258)

460

0.64

Significant

Tumor suppressor gene

CDKN2A

457

302 (57, 245)

155

1.95

Insignificant

Tumor suppressor gene

NF2

385

80 (5, 75)

305

0.26

Significant

Tumor suppressor gene

CEBPA

358

43 (8, 35)

315

0.14

Insignificant

Other

KIT

312

148 (25, 123)

164

0.90

Apparent

Oncogene

TP53

300

232 (5, 227)

68

3.41

Significant

Tumor suppressor gene

EGFR

269

208 (19, 189)

61

3.41

Apparent

Oncogene

CTNNB1

229

143 (17, 126)

86

1.66

Apparent

Oncogene

NOTCH1

222

98 (9, 89)

124

0.79

Apparent

Tumor suppressor gene

PIK3CA

204

190 (9, 181)

14

13.57

Apparent

Oncogene

PTCH1

189

125 (10, 115)

64

1.95

Insignificant

Tumor suppressor gene

NF1

182

83 (5, 78)

99

0.84

Insignificant

Tumor suppressor gene

RB1

174

87 (4, 83)

87

1.00

Significant

Tumor suppressor gene

ATM

162

124 (2, 122)

38

3.26

Insignificant

Other

WT1

156

44 (0, 44)

112

0.39

Apparent

Tumor suppressor gene

SMAD4

147

108 (4, 104)

39

2.77

Insignificant

Tumor suppressor gene

RUNX1

135

60 (6, 54)

75

0.80

Apparent

Tumor suppressor gene

CDH1

133

70 (6, 64)

63

1.11

Insignificant

Tumor suppressor gene

FLT3

124

35 (4, 31)

89

0.39

Apparent

Oncogene

MEN1

122

45 (1, 44)

77

0.58

Insignificant

Tumor suppressor gene

BRAF

118

109 (16, 93)

9

12.11

Apparent

Oncogene

STK11

111

66 (8, 58)

45

1.47

Significant

Tumor suppressor gene

GATA1

106

20 (2, 18)

86

0.23

Apparent

Other

Mean

277

136 (12, 124)

142

0.96

-

-

  1. S/I is the ratio of base substitution number and indel number. S-I represents the linkage between substitutions and indels. In column a, the two numbers in parentheses are synonymous and non-synonymous somatic base substitutions, respectively. Gene type is "Oncogene" or "Tumor suppressor gene" whenever there is strong evidence according to previous publications (otherwise "Other" is assigned).