Table 4 Association analysis for the relationship between validated SNPs in the explored candidate genes and PCOS symptoms (present/absent) with genetic effect sizes estimates derived for an log-additive genetic model (MC4R rs2229616 dominant genetic model) for the minor allele (see also Table 1).

1.29

(0.70;2.37)

0.41

1.15 0.34

(0.87;1.54) (0,59;1.28)

0.33 0.47

0.90

(0.65;1.24)

0.50

0.97

(0.73;1.30)

0.85

0.57

(0.36;0.88)

0.01

1.02

(0.54;1.90)

0.96

1.03 -0.08

(0.76;1.38) (1.06;0.90)

0.87 0.87

1.17

(0.83;1.64)

0.37

1.00

(0.74;1.35)

0.99

1.02

(0.65;1.60)

0.93

0.64

(0.35;1.18)

0.15

0.88 0.09

(0.64;1.21) (0.95;1.12)

0.44 0.87

0.75

(0.51;1.08)

0.12

0.84

(0.61;1.15)

0.28

0.77

(0.48;1.21)

0.25

-

-

-

1.73 -0.39

(0.51;5.84) (4.16;3.38)

0.38 0.84

0.91

(0.24;3.46)

0.89

0.54

(0.16;1.82)

0.32

1.48

(0.18;12.50)

0.71

1.01

(0.52;1.95)

0.98

0.85 0.16

(0.62;1.17) (0.88;1.21)

0.33 0.76

1.01

(0.70;1.44)

0.98

1.04

(0.76;1.43)

0.81

0.95

(0.59;1.52)

0.82

0.74

(0.39;1.39)

0.34

0.97 0.40

(0.71;1.32) (0.60;1.41)

0.83 0.43

1.09

(0.77;1.54)

0.62

1.06

(0.78;1.45)

0.70

1.03

(0.64;1.64)

0.71