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Table 2 Association analysis for the relationship between validated SNPs in the explored candidate genes and quantitative metabolic/obesity related variables in PCOS with genetic effect sizes estimates derived for an additive genetic (MC4R rs2229616 dominant genetic model) for the minor allele (see also Table 1).

From: Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)

 

body weight [kg]

BMI [kg/m2]

waist [cm]

gene (SNP) minor allele

β

95% CI

p

β

95% CI

p

β

95% CI

p

FTO (rs9939609) A

4.60

(0.97;8.22)

0.01

1.56

(0.34;2.78)

0.01

3.49

(0.62;6.37)

0.02

INSIG2 (rs7566605) C

-1.38

(-5.23;2.48)

0.48

-0.35

(-1.66;0.95)

0.59

-1.89

(-4.92;1.15)

0.22

TCF7L2 (rs7903146) T

-4.18

(-8.20;-0.15)

0.04

-1.35

(-2.71;0.01)

0.05

-3.43

(-6.63;-0,24)

0.04

MC4R (rs2229616) T

-2.12

(-16.88;12.63)

0.78

-0.91

(-5.88;4.06)

0.72

1.14

(-10.01;12.29)

0.84

MC4R (rs17782313) C

0.33

(-3.75;4.42)

0.87

-0.01

(-1.36;1.39)

0.98

0.54

(-2.73;3.81)

0.75

MC4R (rs12970134) A

0.20

(-3.74;4.14)

0.92

-0.12

(-1.45;1.21)

0.86

0.52

(-2,64;3.69)

0.75

  1. SNP = single nucleotide polymorphism; BMI = body mass index