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Table 2 Association between the MCF2L2 genetic polymorphisms and diabetic nephropathy

From: Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus

SNP ID

Hit Orientation

Group

Genotype Frequency

Allele Frequency

Association Significance

P-value/Odds ratio (95% CI)

rs35069869

Women

AA

AG

GG

A

G

 

A/G

T1D without DN

174 (0.489)

153 (0.430)

29 (0.081)

0.704

0.211

 
 

T1D with DN

135 (0.509)

109 (0.411)

21 (0.079)

0.715

0.285

0.661 a

 

Men

      
 

T1D without DN

125 (0.519)

101 (0.419)

15 (0.062)

0.728

0.272

 
 

T1D with DN

150 (0.479)

137 (0.438)

26 (0.083)

0.698

0.302

0.273 a

rs35368790

Women

GG

GC

CC

G

C

 

G/C

T1D without DN

168 (0.471)

151 (0.423)

38 (0.106)

0.682

0.318

 
 

T1D with DN

134 (0.511)

107 (0.408)

33 (0.105)

0.716

0.284

0.204 a

 

Men

      
 

T1D without DN

107 (0.442)

110 (0.455)

25 (0.103)

0.669

0.331

 
 

T1D with DN

146 (0.466)

134 (0.428)

33 (0.105)

0.681

0.319

0.696 a

rs7639705

Women

TT

TG

GG

T

G

 

T1165G

T1D without DN

213 (0.603)

125 (0.354)

15 (0.043)

0.780

0.220

 

Leu359Ile

T1D with DN

188 (0.712)

65 (0.246)

11 (0.042)

0.835

0.165

0.017/0.701 (0.524-0.938) a

0.018/0.757 b

 

Men

      
 

T1D without DN

157 (0.651)

73 (0.303)

11 (0.046)

0.803

0.197

 
 

T1D with DN

183 (0.590)

115 (0.371)

12 (0.039)

0.776

0.224

0.275 a

  1. T1D = type 1 diabetes, DN = diabetic nephropathy. Association significances = a. test for allele frequency difference (additive model), and b. for Armitage's trend.