Table 6 Estimated risk for selected demographic characteristic and major risk factors with estrogen receptor-β exon 7, codon 392 in different genotypes
Breast cancer | Yes | No | Pvalue | OR (95% CI) |
|---|---|---|---|---|
Genotype | n = 150 | n = 147 | ||
Normala | 135(47.9%) | 147(52.1%) | 0.029 | 1.0(reference) |
Heterozygoteb | 13(100%) | - | - | |
Homozygotec | 2(100%) | - | - | |
Age at menarche (years) | </= 12 | > 12 | P value | OR (95% CI) |
Genotype | n = 60 | n = 90 | ||
Normal | 50(37.0%) | 85(63%) | 0.437 | 1.0(reference) |
Heterozygote | 9(69.2%) | 4(30.8%) | 0.261(0.077-0.893) | |
Homozygote | 1(50%) | 1(50%) | 0.588(0.036 -9.613) | |
First- degree family history of breast cancer | Affected | Not affected | P value | OR (95% CI) |
Genotype | n = 19 | n = 131 | ||
Normal | 7(5.2%) | 128(94.8%) | 0.001 | 1.0(reference) |
Heterozygote | 10(76.9%) | 3(23.1%) | 0.016(0.004- 0.073) | |
Homozygote | 2(100%) | - | - | |
Lymph node metastases | Yes | No | P value | OR (95% CI) |
Genotype | n = 23 | n = 127 | ||
Normal | 14(10.4%) | 121(89.6%) | 0.001 | 1.0(reference) |
Heterozygote | 7(53.8%) | 6(46.2%) | 0.099(0.029 - 0.337) | |
Homozygote | 2(100%) | - | - |