Skip to main content

Table 5 Allelic frequencies of estrogen receptor-β exon 7, codon 392 (CTC/CTG) in the study population: breast cancer cases versus control groups and breast cancer cases in the presence versus the absence of major risk factors

From: Estrogen Receptor-Beta Gene Polymorphism in women with Breast Cancer at the Imam Khomeini Hospital Complex, Iran

  

ER-β Alleles

Characteristic

 

Ca

Gb

Breast cancer

   

Case

(n = 150)

283(94.3%)

17(5.7%)

Control

(n = 147)

294(100%)

-

  

χ2 = 17.122, P = 0.001

Age at menarche(years)

   

</= 12

(n = 60)

109(90.8%)

11(9.2%)

> 12

(n = 90)

174(96.7%)

6(3.3%)

  

χ2 = 4.583, P = 0.032

Age at menopause (years)

   

=< 50

(n = 47)

87(92.6%)

7(7.4%)

> 50

(n = 12)

24(100%)

-

  

χ2 = 1.884, P = 0.17

ABO blood groups

   

A

(n = 27)

51(94.4%)

3(5.6%)

B

(n = 14)

26(92.9%)

2(7.1%)

AB

(n = 6)

12(100%)

-

O

(n = 103)

194(94.2%)

12(5.8%)

  

χ2 = 0.058, P = 0.81

Race

   

Arab & Armani

(n = 3)

6(100%)

-

Fars

(n = 60)

114(95.0%)

6(5.0%)

Lor & Kurdish

(n = 18)

32(88.9%)

4(11.1%)

Turkish

(n = 46)

88(95.7%)

4(4.3%)

Gilaki & Mazani

(n = 23)

43(93.5%)

3(6.5%)

  

χ2 = 0.05, P = 0.822

Family history of breast cancer

   

First-degree family affected

(n = 19)

24(63.2%)

14(36.8%)

Not affected

(n = 131)

259(98.9%)

3(1.1%)

  

χ2 = 78.847, P = 0.001

Lymph node metastases

   

Yes

(n = 23)

35(76.1%)

11(23.9%)

No

(n = 127)

248(97.6%)

6(2.4%)

  

χ2 = 33.838, P = 0.001

ER expression in breast cancer tissue

   

Positive

(n = 40)

70(87.5%)

10(12.5%)

Negative

(n = 92)

179(97.3%)

5(2.7%)

Not studied

(n = 18)

34(94.4%)

2(5.6%)

  

χ2 = 5.161, P = 0.023

  1. a Allele 392C, CTC, b Allele 392G, CTG