CXCR1 and SLC11A1polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study

Table 4 Haplotype analysis of family data

Disease Phenotype	Haplotypes	Haplotype Frequency	Over/Under Transmitted	rs4674259	rs2854386
CL	T_C	0.47	Over	O = 160; E = 145; χ² _1df = 5.88; P = 0.015
	C_C	0.16	-		O = 62; E = 67; χ² _1df = 2.02; NS
	T_C_C	0.47	Over	O = 152; E = 136; χ² _1df = 6.62; P = 0.010
ML	T_C	0.47	Under	O = 41; E = 49; χ² _1df = 5.19; P = 0.023
	C_C	0.16	-		O = 17; E = 15; χ² _1df = 0.08; NS
	T_C_C	0.47	Under	O = 39; E = 46; χ² _1df = 4.22; P = 0.040
CL or ML	T_C	0.47	-	O = 201; E = 194; χ² _1df = 0.96; NS
	C_C	0.16	-		O = 80; E = 82; χ² _1df = 1.36; NS
	T_C_C	0.47	-	O = 190; E = 181; χ² _1df = 1.59; NS

TRANSMIT haplotype association analysis for SNPs rs4674259_rs2854386_rs2234671 across CXCR2_CXCR1 showing over- and under-transmission for the common haplotypes in families analysed for the CL only phenotype, ML only phenotype, and CL or ML. O = observed number of transmissions; E = expected number of transmissions.

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