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Table 3 FBAT analysis of family data

From: CXCR1 and SLC11A1polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study

Gene/Marker

Phenotype

Model

Allele/Genotype

Allele/Genotype Frequency

# Families

Obs T

Exp T

Z score

Pvalue

CXCR1_rs2854386

CL

Dominant

C

0.83

12

35

29

2.002

0.045

 

ML

Dominant

G

0.17

20

17

12

1.999

0.046

 

ML

Genotype

CC

0.69

20

7

12

-1.999

0.046

 

ML

Genotype

CG1

0.28

22

18

12

2.221

0.026

 

CL+ML

Dominant

C

0.83

12

35

29

2.002

0.045

CXCR1_rs2234671

CL

Dominant

C

0.85

12

36

32

1.563

0.118

 

ML

Dominant

G

0.15

18

14

11

1.604

0.108

 

ML

Genotype

CG

0.30

19

14

9

1.964

0.049

 

CL+ML

Dominant

C

0.85

12

36

32

1.563

0.118

SLC11A1_rs 17235416

CL

Additive

IN

0.86

27

98

88

2.549

0.011

 

ML

Additive

IN

0.86

21

32

32

0.209

0.834

 

CL+ML

Additive

IN

0.86

28

105

95

2.333

0.020

 

CL

Dominant

DEL

0.14

24

30

12

-2.198

0.028

 

ML

Dominant

DEL

0.14

19

9

10

-0.426

0.670

 

CL+ML

Dominant

DEL

0.14

25

25

32

-2.179

0.029

 

CL

Genotype

IN/IN

0.75

24

35

27

2.198

0.028

 

CL

Genotype

IN/DEL2

0.23

27

28

33

-1.206

0.228

 

ML

Genotype

IN/IN

0.75

19

12

11

0.426

0.670

 

ML

Genotype

IN/DEL2

0.23

21

8

10

-1.021

0.307

 

CL+ML

Genotype

IN/IN

0.75

25

38

30

2.179

0.029

 

CL+ML

Genotype

IN/DEL2

0.23

28

29

34

-1.409

0.159

  1. FBAT analysis for transmission of alleles from heterozygous parents to CL, ML and L. braziliensis per se (CL and ML) individuals in families. # families = number of families informative for the FBAT analysis. A positive Z score indicates association with disease; a negative Z score indicates the non-associated or protective allele or genotype. Obs T = observed transmissions; Exp T = expected transmissions. 1Insufficient informative families (# = 4) for the GG genotype (frequency 0.03) to contribute to the analysis; 2Insufficient informative families (# = 5,4,5) for the DEL/DEL genotype (frequency 0.02) to contribute to the analysis for CL, ML or CL+ML.