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Table 3 Association analysis of INSIG2 rs7566605 with the body features of the Kirin population

From: Association analyses of the INSIG2polymorphism in the obesity and cholesterol levels of Korean populations

   

n (mean ± SD)

Group

Phenotype

MAF

G/G

G/C

C/C

Total

WHR

0.35

428(0.888 ± 0.0728)

432(0.885 ± 0.0776)

131(0.887 ± 0.0811)

   

P ANOVA = 0.825, P dom = 0.554, P rec = 0.977

 

Fat mass

0.35

428(24.4 ± 8.36)

432(23.8 ± 8.77)

131(23.8 ± 8.67)

   

P ANOVA = 0.590, P dom = 0.305, P rec = 0.689

 

Fat percent

0.35

428(34.3 ± 5.86)

432(33.9 ± 6.13)

131(34.2 ± 6.58)

   

P ANOVA = 0.526, P dom = 0.318, P rec = 0.869

 

Total AFA

0.35

422(293 ± 123)

430(291 ± 131)

130(280 ± 122)

   

P ANOVA = 0.618, P dom = 0.571, P rec = 0.344

 

Visceral AFA

0.35

422(65.7 ± 43.4)

430(65.5 ± 47.1)

130(60.2 ± 40.3)

   

P ANOVA = 0.439, P dom = 0.626, P rec = 0.164

 

Subcutaneous AFA

0.35

422(228 ± 98.0)

430(225 ± 103)

130(220 ± 101)

   

P ANOVA = 0.758, P dom = 0.569, P rec = 0.519

Female

WHR

0.35

400(0.882 ± 0.0697)

400(0.875 ± 0.0664)

120(0.881 ± 0.0798)

   

P ANOVA = 0.293, P dom = 0.175, P rec = 0.782

 

Fat mass

0.35

400(23.9 ± 8.17)

400(22.9 ± 7.65)

120(23.6 ± 8.64)

   

P ANOVA = 0.228, P dom = 0.123, P rec = 0.845

 

Fat percent

0.35

400(34.5 ± 5.89)

400(33.9 ± 6.14)

120(34.5 ± 6.62)

   

P ANOVA = 0.332, P dom = 0.261, P rec = 0.576

 

Total AFA

0.35

394(285 ± 119)

398(276 ± 118)

119(277 ± 121)

   

P ANOVA = 0.544, P dom = 0.270, P rec = 0.742

 

Visceral AFA

0.35

394(607 ± 369)

398(591 ± 37.8)

119(556 ± 32.9)

   

P ANOVA = 0.399, P dom = 0.313, P rec = 0.192

 

Subcutaneous AFA

0.35

394(225 ± 97.0)

398(217 ± 95.0)

119(221 ± 102)

   

P ANOVA = 0.533, P dom = 0.295, P rec = 0.982

Male

WHR

0.38

28(0.976 ± 0.0598)

32(1.02 ± 0.0891)

11(0.954 ± 0.0656)

   

P ANOVA = 0.0292, P dom = 0.192, P rec = 0.0923

 

Fat mass

0.38

28(31.2 ± 8.18)

32(35.0 ± 13.4)

11(26.1 ± 9.06)

   

P ANOVA = 0.0629, P dom = 0.589, P rec = 0.0510

 

Fat percent

0.38

28(32.4 ± 5.12)

32(33.9 ± 6.19)

11(30.9 ± 5.23)

   

P ANOVA = 0.730, P dom = 0.607, P rec = 0.207

 

Total AFA

0.38

28(406 ± 128)

32(473 ± 146)

11(323 ± 136)

   

P ANOVA = 0.00778, P dom = 0.422, P rec = 0.0120

 

Visceral AFA

0.38

28(135 ± 645)

32(146 ± 726)

11(110 ± 72.0)

   

P ANOVA = 0.345, P dom = 0.928, P rec = 0.213

 

Subcutaneous AFA

0.38

28(271 ± 103)

32(327 ± 139)

11(213 ± 94.3)

   

P ANOVA = 0.0199, P dom = 0.347, P rec = 0.0311

  1. The P values for the AFA in subjects with minor alleles were assessed by an ANOVA for three genotypes or by a T-test for the dominant and recessive models. The significant threshold was 0.0015 for the Kirin population (11 phenotypes and 3 different models).
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BMC Medical Genetics

ISSN: 1471-2350

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