| Genotype |  |  | ||
---|---|---|---|---|---|
 | AA | AG | GG | p b | q |
n (M/F)a | 221 (73/148) | 233 (79/154) | 48 (13/35) | 0.645 | 0.714 |
Age (years) | 56 ± 7 | 55 ± 7 | 53 ± 7 | 0.077c | 0.421 |
Weight (kg) | 86.3 ± 14.6 | 85.8 ± 13.5 | 87.3 ± 15.9 | 0.878 | 0.924 |
BMI (kg/m2) | 31.3 ± 4.8 | 31.1 ± 4.2 | 31.6 ± 5.2 | 0.991 | 0.954 |
Waist-to-hip ratio | 0.92 ± 0.07 | 0.92 ± 0.07 | 0.93 ± 0.08 | 0.583 | 0.067 |
Fasting plasma glucose (mmol/l) | 6.2 ± 0.8 | 6.1 ± 0.7 | 6.2 ± 0.7 | 0.295 | 0.047 |
Fasting serum insulin (pmol/l) | 85 ± 40 | 92 ± 51 | 86 ± 30 | 0.665c | 0.070 |
Serum total cholesterol (mmol/l) | 5.5 ± 0.9 | 5.7 ± 0.9 | 5.9 ± 1.0 | 0.005 | 0.006 |
Serum LDL-cholesterol (mmol/l) | 3.5 ± 0.8 | 3.7 ± 0.8 | 3.9 ± 1.0 | 0.004 | 0.006 |
Serum HDL-cholesterol (mmol/l) | 1.22 ± 0.29 | 1.22 ± 0.30 | 1.17 ± 0.25 | 0.834 | 0.081 |
Serum triglycerides (mmol/l) | 1.69 ± 0.73 | 1.74 ± 0.83 | 1.81 ± 0.70 | 0.558 | 0.066 |
Total cholesterol-to-HDL-cholesterol ratio | 4.73 ± 1.22 | 4.90 ± 1.26 | 5.15 ± 1.15 | 0.045 | 0.013 |
Converters to T2DM (n/%)a | 72/33% | 89/38% | 23/48% | 0.039 | 0.394 |