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Table 3 Summary statistics on haplotype-based association

From: Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study

Gene

SNP identifiers and omnibus association

Haplotype

F patients

F controls

χ2

p

OPTN

rs10796021|rs3829923|rs7921853|rs765884

TTGT

0.257

0.327

5.905

0.015

 

pomnibus = 0.014

CCGT

0.125

0.142

0.590

0.443

 

χ2 omnibus = 23.67

TCTT

0.129

0.119

0.243

0.622

  

CCTC

0.187

0.093

18.170

2.021 × 10-5

  

TCTC

0.062

0.073

0.484

0.487

  

CCTT

0.072

0.070

0.019

0.890

  

CTGT

0.048

0.056

0.293

0.588

  

TTTT

0.036

0.040

0.083

0.773

  

TCGT

0.023

0.031

0.728

0.394

  

CCGC

0.029

0.029

0.003

0.959

  

CTTC

0.014

0.013

0.023

0.880

  

TTGC

0.018

0.009

1.611

0.204

MFN2

rs873458|rs2295281|rs11588779

ATC

0.410

0.420

0.1083

0.742

 

pomnibus = 0.018

GCC

0.359

0.286

6.541

0.011

 

χ2 omnibus = 11.97

ATT

0.091

0.147

8.334

3.891 × 10-3

  

GCT

0.131

0.135

0.039

0.843

  

GTC

0.009

0.011

0.099

0.753

PARL

rs1000002|rs1402003

TA

0.461

0.540

4.049

0.044

 

pomnibus = 7.619 × 10-4

CG

0.464

0.344

9.758

1.786 × 10-3

 

χ2 omnibus = 16.84

CA

0.075

0.093

0.7123

0.399

  

TG

0

0.023

8.480

3.590 × 10-3

  1. F, frequency