SLC6A3and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

BMC Medical Genetics

Table 2 SLC6A3 polymorphisms and haplotypes by body mass index

	Normal	Underweight BMI†				Overweight BMI†				Obese BMI†
Polymorphism	N	N	OR‡	(95% CI)	P	N	OR‡	(95% CI)	P	N	OR‡	(95% CI)	P
SLC6A3 VNTR
**	459	14	1.00	(reference)		514	1.00	(reference)		254	1.00	(reference)
*9	361	12	1.07	(0.48, 2.38)	0.870	390	0.93	(0.76, 1.13)	0.459	159	0.80	(0.62, 1.04)	0.093
99	67	0	~			63	0.81	(0.56, 1.19)	0.284	19	0.47	(0.27, 0.83)	0.009
P for trend								p = 0.246				*p = 0.005*
*9/99			0.91	(0.41, 2.01)	0.809		0.91	(0.75, 1.10)	0.332		0.75	(0.59, 0.96)	0.023
Ex9-55A>G
AA	498	8	1.00	(reference)		539	1.00	(reference)		220	1.00	(reference)
AG	338	14	2.66	(1.08, 6.58)	0.034	369	1.03	(0.85, 1.25)	0.771	193	1.34	(1.04, 1.73)	0.023
GG	59	4	6.12	(1.66, 22.61)	0.007	80	1.25	(0.86, 1.82)	0.234	27	0.99	(0.60, 1.66)	0.981
P for trend				*p = 0.003*				p = 0.329				p = 0.152
AG/GG			3.04	(1.28, 7.24)	0.012		1.06	(0.88, 1.28)	0.533		1.29	(1.01, 1.65)	0.042
Haplotype §
A-C-G-*	795	22	1.00	(reference)		906	1.00	(reference)		419	1.00	(reference)
A-C-G-9	251	3	0.44	(0.13, 1.49)	0.187	252	0.85	(0.69, 1.05)	0.126	84	0.60	(0.45, 0.80)	0.001
A-T-T-*	86	0	~			81	0.90	(0.65, 1.25)	0.529	34	0.79	(0.51, 1.23)	0.298
G-C-G-*	213	10	1.84	(0.83, 4.05)	0.132	242	1.03	(0.83, 1.28)	0.761	124	1.15	(0.88, 1.50)	0.319
G-C-G-9	173	7	1.51	(0.62, 3.70)	0.369	200	1.00	(0.79, 1.26)	0.988	75	0.88	(0.64, 1.20)	0.408

* = an allele other than the SLC6A3*9 allele. These are largely (98.1%) the SLC6A3*10 VNTR allele.
† BMI categorized as Underweight (≤ 18 kg/m²), Normal (18–24.9 kg/m²), Overweight (25–29.9 kg/m²) or Obese (≥ 30 kg/m²).
‡ OR estimated using conditional logistic regression, conditioning on age, sex, current smoking status, number of cigarettes smoked.
§Haplotype analyses were conducted among non-Hispanic Caucasians.

ISSN: 1471-2350