Otitis media: a genome-wide linkage scan with evidence of susceptibility loci within the 17q12 and 10q22.3 regions

Table 1 Additive ALL linkage statistics as computed by Mendel, grouped by peak, for the Caucasian-only data set and for the combined Caucasian and African American data set.

Chromosome	Locus	Physical position	cM	Caucasian P-value	Combined P-value
17	rs11439	30539277	53.18	0.00028	0.00062
17	rs938298	30711529	53.41	0.00022	0.00047
17	rs722374	30770914	53.48	0.00020	0.00042
17	rs226088	31041457	53.75	*0.00007*	*0.00023*
17	rs2680398	32663038	55.69	0.00052	0.00127
10	rs1878001	79048564	99.31	0.00181	0.00039
10	rs2244688	79076786	99.34	0.00183	0.00039
10	rs2812415	79076976	99.35	0.00185	0.00039
10	rs719871	79815441	100.11	0.00215	*0.00026*
10	rs1369752	79918761	100.23	0.00223	0.00027
7	rs1343697	132603523	139.97	0.00118	0.00115
7	rs718656	132771392	140.06	0.00106	0.00110
7	rs958408	132791458	140.08	0.00105	0.00111
7	rs1073158	133116548	140.27	0.00123	0.00128
7	rs958404	133247726	140.33	0.00127	0.00132
6	rs1112267	4873386	15.03	0.00330	0.00921
6	rs2326584	5234205	16.06	0.00304	0.00962
6	rs2326689	5966877	17.94	0.00312	0.00786
6	rs1902946	6313577	18.81	0.00276	0.00649
6	rs554653	6492486	19.23	0.00261	0.00569
4	rs2133507	24779140	40.67	0.00301	0.00521
4	rs1402031	25204628	41.72	0.00365	0.00469
4	rs939353	25204915	41.73	0.00366	0.00467
4	rs1378943	25382169	42.20	0.00339	0.00461
4	rs1378946	25382548	42.21	0.00338	0.00463

For each peak, we list the 5 SNPs that are most significant in the Caucasian data set. Bold indicates a p-value less than 0.0005; the minimum p-value in each region is in italics.

ISSN: 1471-2350