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Table 2 Clinical characteristics of subjects studied

From: The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population

 

Diabetic subjects

Control subjects

rs2071023

CC

CG

GG

CC

CG

GG

BMI (kg/m2)

28.8 ± 4.6

28.4 ± 4.7

28.9 ± 4.7

28.5 ± 5.2

27.7 ± 4.8

28.3 ± 4.1

Waist circumference (cm)

102.8 ± 10.5

102.1 ± 11.0

103.0 ± 10.0

100.1 ± 13.4

98.8 ± 11.5

101.5 ± 13.7

Systolic blood pressure (mm Hg)

140.6 ± 20.6

139.7 ± 20.1

141.1 ± 22.7

134.4 ± 19.3

135.2 ± 20.5

136.3 ± 22.2

Diastolic blood pressure (mm Hg)

84.0 ± 11.5

84.2 ± 13.2

85.2 ± 11.8

84.8 ± 11.2

84.2 ± 12.2

84.1 ± 12.7

HDL cholesterol (mmol/l)

1.3 ± 0.5

1.3 ± 0.5

1.3 ± 0.5

ND

ND

ND

HbA1c (%)

8.3 ± 1.8

8.2 ± 1.8

8.4 ± 2.1

ND

ND

ND

rs6070157

CC

CT

TT

CC

CT

TT

BMI (kg/m2)

28.6 ± 4.7

28.6 ± 4.8

28.0 ± 3.4

28.0 ± 4.7

28.1 ± 5.0

28.7 ± 5.3

Waist circumference (cm)

102.5 ± 10.3

102.4 ± 11.0

102.0 ± 13.4

99.5 ± 13.0

99.0 ± 12.1

103.8 ± 10.4

Systolic blood pressure (mm Hg)

140.1 ± 20.9

140.5 ± 20.5

139.3 ± 19.9

133.9 ± 20.5

136.6 ± 20.1

139.6 ± 20.3

Diastolic blood pressure (mm Hg)

84.3 ± 11.7

84.6 ± 14.4

83.9 ± 7.9

83.6 ± 12.0

85.5 ± 12.3

86.4 ± 9.9

HDL cholesterol (mmol/l)

1.3 ± 0.5

1.3 ± 0.5

1.2 ± 0.3

ND

ND

ND

HbA1c (%)

8.4 ± 2.0

8.2 ± 1.7

8.0 ± 1.6

ND

ND

ND

rs2070756

CC

CT

TT

CC

CT

TT

BMI (kg/m2)

28.5 ± 4.5

28.7 ± 4.8

28.3 ± 4.5

28.0 ± 4.9

27.9 ± 4.8

29.1 ± 5.0

Waist circumference (cm)

102.2 ± 10.7

102.8 ± 10.6

102.3 ± 10.2

99.4 ± 12.3

99.3 ± 12.9

102.7 ± 13.8

Systolic blood pressure (mm Hg)

139.6 ± 20.5

141.8 ± 21.6

138.7 ± 19.1

134.7 ± 20.3

136.9 ± 20.7

132.8 ± 19.5

Diastolic blood pressure (mm Hg)

84.7 ± 13.0

84.3 ± 12.0

83.5 ± 10.4

84.8 ± 11.5

84.0 ± 12.0

84.1 ± 14.2

HDL cholesterol (mmol/l)

1.3 ± 0.5

1.3 ± 0.5

1.3 ± 0.4

ND

ND

ND

HbA1c (%)

8.2 ± 1.9

8.3 ± 1.8

8.5 ± 2.1

ND

ND

ND

rs2179706

CC

CT

TT

CC

CT

TT

BMI (kg/m2)

28.7 ± 4.9

28.5 ± 4.6

28.5 ± 4.4

28.5 ± 4.6

27.8 ± 4.8

27.8 ± 5.1

Waist circumference (cm)

103.0 ± 10.5

102.0 ± 10.7

102.4 ± 10.8

102.6 ± 13.8

98.1 ± 11.7

98.3 ± 12.1

Systolic blood pressure (mm Hg)

141.2 ± 20.8

140.2 ± 21.7

139.2 ± 18.7

134.4 ± 21.0

135.0 ± 19.6

137.0 ± 21.0

Diastolic blood pressure (mm Hg)

84.8 ± 11.1

83.9 ± 13.9

85.3 ± 10.5

83.5 ± 12.2

85.1 ± 12.0

84.7 ± 11.0

HDL cholesterol (mmol/l)

1.3 ± 0.5

1.3 ± 0.5

1.2 ± 0.3

ND

ND

ND

HbA1c (%)

8.4 ± 2.0

8.3 ± 1.8

8.0 ± 1.7

ND

ND

ND

rs1042531

TT

GT

GG

TT

GT

GG

BMI (kg/m2)

28.4 ± 4.4

28.9 ± 4.8

28.4 ± 5.2

28.2 ± 5.1

27.5 ± 4.6

29.1 ± 4.0

Waist circumference (cm)

102.2 ± 10.2

103.1 ± 11.0

101.3 ± 11.2

99.7 ± 13.0

99.1 ± 11.3

101.5 ± 17.1

Systolic blood pressure (mm Hg)

139.2 ± 20.3

140.2 ± 20.6

144.5 ± 22.8

135.9 ± 20.0

136.1 ± 20.2

128.3 ± 22.2

Diastolic blood pressure (mm Hg)

83.6 ± 11.0

84.8 ± 14.1

85.8 ± 10.4

85.4 ± 11.6

84.0 ± 12.2

82.4 ± 12.5

HDL cholesterol (mmol/l)

1.3 ± 0.4

1.3 ± 0.5

1.3 ± 0.6

ND

ND

ND

HbA1c (%)

8.2 ± 1.8

8.3 ± 1.8

8.5 ± 2.4

ND

ND

ND

  1. Genotypes of the studied PCK1 variants were not significantly associated with any measured clinical characteristic (ANOVA; p > 0.05 for all tests). Data are expressed as means ± SD. ND = not determined.