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Table 2 Haplotype association analysis between CDK5 gene and AD stratified by APOE ε4 allele

From: No association of CDK5 genetic variants with Alzheimer's disease risk

CDK5 haplotype

APOE e4 allele noncarriers

 

APOE e4 allele carriers

 

Total sample

 
 

AD, control frequency

p-value

AD, control frequency

p-value

AD, control frequency

p-value

GTGGGC

0.29, 0.31

0.30

0.29, 0.33

0.36

0.29, 0.31

0.30

GGGGGG

0.16, 0.17

0.59

0.14, 0.18

0.21

0.16, 0.17

0.59

GGGGAC

0.14, 0.12

0.16

0.15, 0.09

0.07

0.14, 0.12

0.16

AGGGGC

0.12, 0.11

0.57

0.14, 0.14

0.94

0.12, 0.11

0.57

GTAGGC

0.09, 0.10

0.74

0.07, 0.08

0.91

0.09, 0.10

0.74

GGAGGG

0.06, 0.05

0.53

0.06, 0.05

0.66

0.06, 0.05

0.53

  1. Haplotype block consists of SNPs: rs9278, rs2069459, rs891507, rs2069454, rs1549759 and rs2069442. Rare haplotypes (total frequency < 0.05) were excluded from the analysis. P-values were not corrected for multiple comparisons.