From: No association of CDK5 genetic variants with Alzheimer's disease risk
CDK5 polymorphism | APOE ε4 allele noncarriers | APOE ε4 allele carriers | Total sample | ||||
---|---|---|---|---|---|---|---|
Patients | Controls | Patients | Controls | Patients | Controls | ||
rs9278 | GG | 125 (0.67) | 259 (0.71) | 145 (0.66) | 55 (0.71) | 270 (0.66) | 314 (0.71) |
GA | 61 (0.33) | 96 (0.26) | 69 (0.31) | 22 (0.28) | 130 (0.32) | 118 (0.27) | |
AA | 1 (0.00) | 10 (0.03) | 7 (0.03) | 1 (0.01) | 8 (0.02) | 11 (0.02) | |
Total | 187 | 365 | 221 | 78 | 408 | 443 | |
Allele frequency G/A | 0.83/0.17 | 0.84/0.16 | 0.81/0.19 | 0.85/0.15 | 0.82/0.18 | 0.84/0.16 | |
rs2069459 | GG | 60 (0.34) | 116 (0.32) | 74 (0.35) | 23 (0.29) | 134 (0.34) | 139 (0.31) |
GT | 83 (0.47) | 169 (0.46) | 100 (0.47) | 39 (0.50) | 183 (0.47) | 208 (0.47) | |
TT | 33 (0.19) | 81 (0.22) | 39 (0.18) | 16 (0.21) | 72 (0.19) | 97 (0.22) | |
Total | 176 | 366 | 213 | 78 | 389 | 444 | |
Allele frequency G/T | 0.58/0.42 | 0.55/0.45 | 0.58/0.42 | 0.54/0.46 | 0.58/0.42 | 0.55/0.45 | |
rs891507 | GG | 101 (0.58) | 211 (0.58) | 123 (0.60) | 48 (0.64) | 224 (0.59) | 259 (0.59) |
GA | 60 (0.35) | 135 (0.37) | 73 (0.36) | 24 (0.32) | 133 (0.35) | 159 (0.36) | |
AA | 12 (0.07) | 16 (0.05) | 9 (0.04) | 3 (0.04) | 21 (0.06) | 19 (0.05) | |
Total | 173 | 362 | 205 | 75 | 378 | 437 | |
Allele frequency G/A | 0.76/0.24 | 0.77/0.23 | 0.78/0.22 | 0.80/0.20 | 0.77/0.23 | 0.77/0.23 | |
rs2069454 | GG | 171 (0.97) | 320 (0.91) | 199 (0.93) | 68 (0.91) | 370 (0.94) | 388 (0.91) |
GC | 6 (0.03) | 30 (0.09) | 16 (0.07) | 7 (0.09) | 22 (0.06) | 37 (0.09) | |
CC | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | 0 (0.00) | |
Total | 177 | 350 | 215 | 75 | 392 | 425 | |
Allele frequency G/C | 0.98/0.02 | 0.96/0.04 | 0.96/0.04 | 0.95/0.05 | 0.97/0.03 | 0.96/0.04 | |
rs1549759 | GG | 112 (0.69) | 244 (0.70) | 134 (0.67) | 57 (0.74) | 246 (0.68) | 301 (0.70) |
GA | 48 (0.30) | 100 (0.28) | 59 (0.30) | 20 (0.26) | 107 (0.30) | 120 (0.28) | |
AA | 2 (0.01) | 7 (0.02) | 6 (0.03) | 0 (0.00) | 8 (0.02) | 7 (0.02) | |
Total | 162 | 351 | 199 | 77 | 361 | 428 | |
Allele frequency G/A | 0.84/0.16 | 0.84/0.16 | 0.82/0.18 | 0.87/0.13 | 0.83/0.17 | 0.84/0.16 | |
rs2069442 | CC | 93 (0.55) | 204 (0.60) | 127 (0.63) | 40 (0.57) | 220 (0.60) | 244 (0.59) |
CG | 65 (0.39) | 121 (0.35) | 60 (0.30) | 25 (0.36) | 125 (0.34) | 146 (0.35) | |
GG | 10 (0.06) | 18 (0.05) | 14 (0.07) | 5 (0.07) | 24 (0.06) | 23 (0.06) | |
Total | 168 | 343 | 201 | 70 | 369 | 413 | |
Allele frequency C/G | 0.75/0.25 | 0.76/0.24 | 0.78/0.22 | 0.75/0.25 | 0.77/0.23 | 0.77/0.23 |